Evidence map›Paper›PMID 31694453›Full record

ArticleVirulence2019

The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in

Thomas Orasch, Anna-Maria Dietl, Yana Shadkchan, Ulrike Binder, Ingo Bauer, Cornelia Lass-Flörl, Nir Osherov, Hubertus Haas

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Leucine auxotrophic marker for genetic manipulation ofApplied and environmental microbiology · 2026
    Article
  2. Proteomic and Secretomic Response of an AfricanJournal of proteome research · 2026
    Article
  3. Article
  4. Article
  5. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  6. The Role ofInternational journal of molecular sciences · 2025
    Article
  7. Article
  8. Linalool exhibit antimicrobial ability againstCurrent research in microbial sciences · 2025
    Article
  9. Review
  10. Microevolution during Chronic Infection May LeadDermatology research and practice · 2024
    Article
  11. The Response ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Regulation of the Leucine Metabolism inJournal of fungi (Basel, Switzerland) · 2022
    Article
  16. Comparative proteomics ofOne health (Amsterdam, Netherlands) · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Thomas OraschInstitute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-4653-4932
Anna-Maria DietlInstitute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.
Yana ShadkchanAspergillus and Antifungal Research Laboratory, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Ulrike BinderInstitute of Hygiene & Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Ingo BauerInstitute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-3316-7769
Cornelia Lass-FlörlInstitute of Hygiene & Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Nir OsherovAspergillus and Antifungal Research Laboratory, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Hubertus HaasInstitute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATTel Aviv University · IL

Funding

Austrian Science Fund FWF W 1253
6 · The paper itself

Abstract

In contrast to mammalia, fungi are able to synthesize the branched-chain amino acid leucine

Indexed as

VirulenceAdaptation, PhysiologicalAnimalsAspergillus fumigatusBacterial ProteinsBiosynthetic PathwaysFemaleFungal ProteinsGene Expression Regulation, FungalHomeostasisHydro-LyasesIronLarvaLeucineMiceMice, Inbred ICRBacterial ProteinsFungal ProteinsHydro-LyasesIronLeucineLeuC protein, bacteriaamino acid biosynthesisAspergillus fumigatusironleucinevirulence

Identifiers

PMID31694453
PMCPMC6844326
OpenAlexW2984267692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.