Evidence map›Paper›PMID 31694342›Full record

ReviewGenes2019

Non-Coding RNA and Tumor Development in Neurofibromatosis Type 1:

Viviana Tritto, Luca Ferrari, Silvia Esposito, Paola Zuccotti, Donatella Bianchessi, Federica Natacci, Veronica Saletti, Marica Eoli, Paola Riva

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Biomarker Landscape in RASopathies.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
  5. New insights into the molecular basis of spinal neurofibromatosis type 1.European journal of human genetics : EJHG · 2023
    Article
  6. Plumbing mysterious RNAs in "dark genome" for the conquest of human diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
  7. Article
  8. Article
  9. The lncRNAJournal of inflammation research · 2021
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Viviana TrittoDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, via F.lli Cervi 93, Segrate, 20090 Milan, Italy.
Luca FerrariDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, via F.lli Cervi 93, Segrate, 20090 Milan, Italy.ORCID 0000-0003-0103-2170
Silvia EspositoUnit of Developmental Neurology, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, via Celoria 11, 20133 Milan, Italy.ORCID 0000-0002-6330-2562
Paola ZuccottiDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, via F.lli Cervi 93, Segrate, 20090 Milan, Italy.
Donatella BianchessiUnit of Molecular Neuro-Oncology, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, via Celoria 11, 20133 Milan, Italy.ORCID 0000-0002-6313-0377
Federica NatacciUnit of Medical Genetics, Fondazione I.R.C.C.S. Ca' Granda Ospedale Maggiore Policlinico, via della Commenda 12, 20122 Milan, Italy.ORCID 0000-0002-8625-3089
Veronica SalettiUnit of Developmental Neurology, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, via Celoria 11, 20133 Milan, Italy.ORCID 0000-0003-4830-6204
Marica EoliUnit of Molecular Neuro-Oncology, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, via Celoria 11, 20133 Milan, Italy.ORCID 0000-0003-4744-9377
Paola RivaDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, via F.lli Cervi 93, Segrate, 20090 Milan, Italy.ORCID 0000-0001-6481-8467
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITUniversity of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) are known to regulate gene expression at the transcriptional and post-transcriptional levels, chromatin remodeling, and signal transduction. The identification of different species of ncRNAs, microRNAs (miRNAs), circular RNAs (circRNAs), and long ncRNAs (lncRNAs)-and in some cases, their combined regulatory function on specific target genes-may help to elucidate their role in biological processes. NcRNAs' deregulation has an impact on the impairment of physiological programs, driving cells in cancer development. We here carried out a review of literature concerning the implication of ncRNAs on tumor development in neurofibromatosis type 1 (NF1), an inherited tumor predisposition syndrome. A number of miRNAs and a lncRNA has been implicated in NF1-associated tumors, such as malignant peripheral nerve sheath tumors (MPNSTs) and astrocytoma, as well as in the pathognomonic neurofibromas. Some authors reported that the lncRNA

Indexed as

AstrocytomaGenes, Neurofibromatosis 1GenotypeHumansLoss of HeterozygosityMicroRNAsNerve Sheath NeoplasmsNeurofibromaNeurofibroma, PlexiformNeurofibromatosis 1Optic Nerve GliomaPhenotypeRNA, Long NoncodingRNA, UntranslatedSignal TransductionCDKN2B antisense RNA, humanMicroRNAsRNA, Long NoncodingRNA, UntranslatedANRIL variantsmild NF1 phenotypencRNAneurofibromatosis type 1optic gliomatumor development

Identifiers

PMID31694342
PMCPMC6895873
OpenAlexW2983455382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.