ArticleJournal of clinical medicine2019
CMR Tissue Characterization in Patients with HFmrEF.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05122793 ("HerzCheck" - Erkennung Und Prävention Einer Frühen Herzinsuffizienz Mittels Telemedizinischer Verfahren in Strukturschwachen Regionen), which is not on this map. Cited by 31 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"HerzCheck" - Erkennung Und Prävention Einer Frühen Herzinsuffizienz Mittels Telemedizinischer Verfahren in Strukturschwachen Regionen
Who cites it
31 citing papers in PubMed.
- Apical-Predominant Myocardial Fibrosis in Hypertensive Heart Disease Revealed by CMR Feature Tracking and T1 Mapping.International journal of general medicine · 2026Article
- Reference Values for Myocardial Strain by Cardiac Magnetic Resonance Feature Tracking: Insights From Healthy Volunteers and Heart Failure Patients Using Caas MR.Reviews in cardiovascular medicine · 2026Article
- Adrenomedullin production by adult cardiac fibroblasts via NF-κB/STAT6 signaling enhances post-infarction lymphangiogenesis and cardiac repair.Scientific reports · 2025Article
- Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria-A Long-Term CMR Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging.Frontiers in cardiovascular medicine · 2025Article
- Clinical Applications of Cardiac Magnetic Resonance Parametric Mapping.Diagnostics (Basel, Switzerland) · 2024Review
- Role of Cardiac Magnetic Resonance in Inflammatory and Infiltrative Cardiomyopathies: A Narrative Review.Journal of clinical medicine · 2024Review
- Reduced dynamic changes in pulmonary artery compliance during isometric handgrip exercise in patients with heart failure.Scientific reports · 2024Article
- CMR-based cardiac phenotyping in different forms of heart failure.The international journal of cardiovascular imaging · 2024Article
- A simplified approach to discriminate between healthy subjects and patients with heart failure using cardiac magnetic resonance myocardial deformation imaging.European heart journal. Imaging methods and practice · 2024Article
- Noninvasive evaluation of pulmonary artery stiffness in heart failure patients via cardiovascular magnetic resonance.Scientific reports · 2023Article
- Fusion Modeling: Combining Clinical and Imaging Data to Advance Cardiac Care.Circulation. Cardiovascular imaging · 2023Review
- Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts.Communications biology · 2023Article
- Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study.Diagnostics (Basel, Switzerland) · 2023Article
- Half-Dose versus Single-Dose Gadobutrol for Extracellular Volume Measurements in Cardiac Magnetic Resonance.Journal of cardiovascular development and disease · 2023Article
- Heart failure with mildly reduced ejection fraction: from diagnosis to treatment. Gaps and dilemmas in current clinical practice.Heart failure reviews · 2023Review
- Reduced functional capacity is associated with the proportion of impaired myocardial deformation assessed in heart failure patients by CMR.Frontiers in cardiovascular medicine · 2023Article
- Left ventricular function and coronary microcirculation in patients with mild reduced ejection fraction after STEMI.BMC cardiovascular disorders · 2022Article
- CMR findings after COVID-19 and after COVID-19-vaccination-same but different?The international journal of cardiovascular imaging · 2022Article
- T2 mapping in myocardial disease: a comprehensive review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristics and optimal management of heart failure with a moderately reduced ejection fraction (HFmrEF, LV-EF 40-50%) are still unclear. Advanced cardiac MRI offers information about function, fibrosis and inflammation of the myocardium, and might help to characterize HFmrEF in terms of adverse cardiac remodeling. We, therefore, examined 17 patients with HFpEF, 18 with HFmrEF, 17 with HFrEF and 17 healthy, age-matched controls with cardiac MRI (Phillips 1.5 T). T1 and T2 relaxation time mapping was performed and the extracellular volume (ECV) was calculated. Global circumferential (GCS) and longitudinal strain (GLS) were derived from cine images. GLS (-15.7 ± 2.1) and GCS (-19.9 ± 4.1) were moderately reduced in HFmrEF, resembling systolic dysfunction. Native T1 relaxation times were elevated in HFmrEF (1027 ± 40 ms) and HFrEF (1033 ± 54 ms) compared to healthy controls (972 ± 31 ms) and HFpEF (985 ± 32 ms). T2 relaxation times were elevated in HFmrEF (55.4 ± 3.4 ms) and HFrEF (56.0 ± 6.0 ms) compared to healthy controls (50.6 ± 2.1 ms). Differences in ECV did not reach statistical significance. HFmrEF differs from healthy controls and shares similarities with HFrEF in cardiac MRI parameters of fibrosis and inflammation.
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