Evidence map›Paper›PMID 31694222›Full record

ReviewCancers2019

TYK2: An Upstream Kinase of STATs in Cancer.

Katharina Wöss, Natalija Simonović, Birgit Strobl, Sabine Macho-Maschler, Mathias Müller

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  16. Identification of 8-gene risk prediction signature associated withJournal of gastrointestinal oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katharina WössInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.
Natalija SimonovićInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.
Birgit StroblInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.
Sabine Macho-MaschlerInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.
Mathias MüllerInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.ORCID 0000-0002-7879-3552
University of Veterinary Medicine Vienna · AT

Funding

Austrian Science Fund DK1212 SFBF6101 SFBF6106 DOC32-B28
6 · The paper itself

Abstract

In this review we concentrate on the recent findings describing the oncogenic potential of the protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 functions in cytokine responses and carcinogenesis focusses on the activation of the signal transducers and activators of transcription (STAT) 3 and 5. Insight gained from loss-of-function (LOF) gene-modified mice and human patients homozygous for

Indexed as

cytokine receptor signalinggain-of-function mutationJAK family of protein tyrosine kinasessignal transducer and activator of transcriptiontumorigenesistyrosine kinase 2

Identifiers

PMID31694222
PMCPMC6896190
OpenAlexW2983584640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.