ArticleBioscience reports2019
Development and validation of nomogram combining serum biomarker for predicting survival in patients with resected rectal cancer.
Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Prognostic nomogram for overall survival in rectal cancer with synchronous lung metastases using Surveillance, Epidemiology, and End Results data and a single-center external validation cohort.Journal of gastrointestinal oncology · 2025Article
- Article
- Development and validation of a competitive risk model in patients with rectal cancer: based on SEER database.European journal of medical research · 2023Article
- The effect of BMI on long-term outcome in patients with rectal cancer and establishment of a nomogram prediction model.BMC gastroenterology · 2023Article
- Development and validation of a prognostic nomogram for rectal cancer patients who underwent surgical resection.Pathology oncology research : POR · 2023Article
- Analysis of Prognostic Factors of Rectal Cancer and Construction of a Prognostic Prediction Model Based on Bayesian Network.Frontiers in public health · 2022Article
- Nomogram to Predict the Overall Survival of Colorectal Cancer Patients: A Multicenter National Study.International journal of environmental research and public health · 2021Article
- Accurate nomograms with excellent clinical value for locally advanced rectal cancer.Annals of translational medicine · 2021Article
- Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients.International journal of medical sciences · 2021Article
- Clinical study of colorectal cancer operation: Survival analysis.Korean journal of clinical oncology · 2020Article
- Prognostic Nomogram for Patients with Radical Surgery for Non-Metastatic Colorectal Cancer Incorporating Hematological Biomarkers and Clinical Characteristics.OncoTargets and therapy · 2020Article
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5 authors.
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Abstract
purposeNomogram is a widely used tool that precisely predicts individualized cancer prognoses. We aimed to develop and validate a reliable nomogram including serum tumor biomarkers to predict individual overall survival (OS) for patients with resected rectal cancer (RC) and compare the predictive value with the American Joint Committee on Cancer (AJCC) stages. PATIENTS AND
methodsWe analyzed 520 patients who were diagnosed with non-metastatic rectal cancer as training cohort. External validation was performed in a cohort of 11851 patients from the Surveillance, Epidemiology, and End Results (SEER) database. Independent prognostic factors were identified and integrated to build a nomogram using the Cox proportional hazard regression model. The nomogram was evaluated by Harrell's concordance index (C-index) and calibration plots in both training and validation cohort.
resultsThe calibration curves for probability of 1-, 3-, and 5-year OS in both cohorts showed favorable accordance between the nomogram prediction and the actual observation. The C-indices of the nomograms to predict OS were 0.71 in training cohort and 0.69 in the SEER cohort, which were higher than that of the seventh edition American Joint Committee on Cancer TNM staging system for predicting OS (training cohort, 0.71 vs. 0.58, respectively; P-value < 0.001; validation cohort, 0.69 vs. 0.57, respectively; P-value < 0.001).
conclusionWe developed and validated a novel nomogram based on CEA and other factors for predicting OS in patients with resected RC, which could assist clinical decision making and improvement of prognosis prediction for individual RC patients after surgery.
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