ArticlePLoS genetics2019
Systems genomics approaches provide new insights into Arabidopsis thaliana root growth regulation under combinatorial mineral nutrient limitation.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Genome-wide association studies meta-analysis uncovers NOJO and SGS3 novel genes involved in Arabidopsis thaliana primary root development and plasticity.Molecular biology reports · 2024Pooled it
- GWAS reveal SUBER GENE1-mediated suberization via type one phosphatases.Nature plants · 2026Article
- Article
- Synergistic nutrient uptake and utilization in maize varieties with different nitrogen efficiencies.Frontiers in plant science · 2026Article
- Integrating multi-omics approaches to shape legume root system architecture under drought stress: a comprehensive review.Frontiers in plant science · 2026Review
- Article
- The Phosphorus-Iron Nexus: Decoding the Nutrients Interaction in Soil and Plant.International journal of molecular sciences · 2024Review
- Recent advances in research on phosphate starvation signaling in plants.Journal of plant research · 2024Review
- CLAVATA signaling in plant-environment interactions.Plant physiology · 2024Review
- Genome-Wide Association Study (GWAS) for Identifying SNPs and Genes Related to Phosphate-Induced Phenotypic Traits in Tomato (Plants (Basel, Switzerland) · 2024Article
- A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis.Nature communications · 2024Article
- Combined Approach of GWAS and Phylogenetic Analyses to Identify New Candidate Genes That Participate inPlants (Basel, Switzerland) · 2022Article
- An allelic variant in the ACS7 gene promotes primary root growth in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Phosphate transporter PHT1;1 is a key determinant of phosphorus acquisition in Arabidopsis natural accessions.Plant physiology · 2022Article
- A tale of two players: the role of phosphate in iron and zinc homeostatic interactions.Planta · 2022Review
- Sulfur signaling and starvation response in Arabidopsis.iScience · 2022Review
- Quantitative trait loci mapping reveals important genomic regions controlling root architecture and shoot biomass under nitrogen, phosphorus, and potassium stress in rapeseed (Frontiers in plant science · 2022Article
- To grow or not to grow under nutrient scarcity: Target of rapamycin-ethylene is the question.Frontiers in plant science · 2022Review
- VDAC1 Negatively Regulates Floral Transition inInternational journal of molecular sciences · 2021Article
- Using natural variation to understand plant responses to iron availability.Journal of experimental botany · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
The molecular mechanisms by which plants modulate their root growth rate (RGR) in response to nutrient deficiency are largely unknown. Using Arabidopsis thaliana accessions, we analyzed RGR variation under combinatorial mineral nutrient deficiencies involving phosphorus (P), iron (Fe), and zinc (Zn). While -P stimulated early RGR of most accessions, -Fe or -Zn reduced it. The combination of either -P-Fe or -P-Zn led to suppression of the growth inhibition exerted by -Fe or -Zn alone. Surprisingly, root growth responses of the reference accession Columbia (Col-0) were not representative of the species under -P nor -Zn. Using a systems approach that combines GWAS, network-based candidate identification, and reverse genetic screen, we identified new genes that regulate root growth in -P-Fe: VIM1, FH6, and VDAC3. Our findings provide a framework to systematically identifying favorable allelic variations to improve root growth, and to better understand how plants sense and respond to multiple environmental cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.