ReviewCurrent opinion in pediatrics2019
Recent developments in understanding the mechanisms of food allergy.
Review in Current opinion in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026Article
- Association rule analysis of food-specific IgG and clinical symptoms in pediatric patients.Frontiers in immunology · 2026Article
- The Microecological-Immune Axis in Pediatric Allergic Diseases: Imbalance Mechanisms and Regulatory Interventions.Nutrients · 2025Review
- Food-specific IgG antibodies and body mass index: multivariate analysis of clinical correlations in underweight populations.Frontiers in immunology · 2025Article
- Review
- A Catastrophic Biodiversity Loss in the Environment Is Being Replicated on the Skin Microbiome: Is This a Major Contributor to the Chronic Disease Epidemic?Microorganisms · 2023Article
- Defining Biomarkers to Predict Natural Resolution in Shrimp Allergy.Allergy, asthma & immunology research · 2022Article
- Clinical Manifestations of Pediatric Food Allergy: a Contemporary Review.Clinical reviews in allergy & immunology · 2022Review
- Food Allergy a Constant Concern to the Medical World and Healthcare Providers: Practical Aspects.Life (Basel, Switzerland) · 2021Review
- Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective.Nutrients · 2021Review
- Genetics of Food Allergy.Immunology and allergy clinics of North America · 2021Review
- An Update on the Assessment and Management of Pediatric Abdominal Pain.Pediatric health, medicine and therapeutics · 2021Review
- Contribution of Gut Microbiota to Immune Tolerance in Infants.Journal of immunology research · 2021Review
- Food allergy: an updated review on pathogenesis, diagnosis, prevention and management.Acta bio-medica : Atenei Parmensis · 2020Review
- Role of the Microbiome in Allergic Disease Development.Current allergy and asthma reports · 2020Review
- New Perspectives in Food Allergy.International journal of molecular sciences · 2020Review
- Recent advances in mechanisms of food allergy and anaphylaxis.F1000Research · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe prevalence of food allergy is rising globally. This review will discuss recent discoveries regarding the immunologic mechanisms that drive the initial sensitization and allergic response to food antigens, which may inform prevention and treatment strategies. RECENT
findingsTolerance to food antigens is antigen-specific and promoted by oral exposure early in life and maternal transfer of immune complexes via breast milk. IgG can inhibit both the initiation and effector phases of allergic responses to food antigens in mice, and high levels of food-specific IgG4 are associated with acquisition of tolerance in humans. Disruption of the skin barrier provides a route for food sensitization through the actions of mast cells, type 2 innate lymphoid cells, and IL-33 signaling. Regulatory T cells (Tregs) promote acquisition of oral tolerance, although defects in circulating allergen-specific Tregs are not evident in children with established food allergy. Certain microbes can offer protection against the development of IgE and food allergic responses, while dysbiosis increases susceptibility to food allergy. SUMMARY: Tolerance to food antigens is antigen-specific and is promoted by oral exposure early in life, maternal transfer of immune complexes, food-specific IgG, Tregs, an intact skin barrier, and a healthy microbiome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.