ReviewCurrent opinion in pediatrics2019
Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease.
Review in Current opinion in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Trial
- Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Postoperative S100B protein levels as a measure for predicting neurological deficit in children undergoing cardiac surgery.Frontiers in cardiovascular medicine · 2026Article
- Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newborns.BMC medical genomics · 2025Article
- Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes.Journal of the American Heart Association · 2025Article
- Hybrid approach: a prospective option for treating congenital heart defects in pediatric patients.Frontiers in cardiovascular medicine · 2025Review
- Radiomics with structural magnetic resonance imaging, surface morphometry features, neurology scales, and clinical metrics to evaluate the neurodevelopment of preschool children with corrected tetralogy of Fallot.Translational pediatrics · 2024Article
- Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI.Insights into imaging · 2024Article
- Predictors of the inability to achieve full oral feeding in postoperative infants with CHD.Cardiology in the young · 2024Article
- Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants: a secondary analysis of the PEPaNIC trial.European journal of pediatrics · 2024Article
- Evaluation of Neurological and Auditory Development in Children with Congenital Heart Disease using Essence Q Questionnaire and Auditory Brainstem Response (ABR) Test.Iranian journal of child neurology · 2024Article
- Article
- Serum Markers of Brain Injury in Pediatric Patients with Congenital Heart Defects Undergoing Cardiac Surgery: Diagnostic and Prognostic Role.Clinics and practice · 2023Article
- Early post-operative neurodevelopment and visual assessment in neonates with congenital heart disease undergoing cardiac surgery.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Core components of a rehabilitation program in pediatric cardiac disease.Frontiers in pediatrics · 2023Review
- Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine.Pediatric research · 2022Article
- Article
- Fetal origin of brain dysmaturation in congenital heart disease - Challenges and opportunities for interventions.Journal of neonatal-perinatal medicine · 2022Article
- Therapeutic hypothermia for encephalopathic newborns with congenital heart defect: A cross-sectional survey on current practices and opinions in Germany.Frontiers in pediatrics · 2022Article
- Contribution of Congenital Heart Disorders Associated With Copy Number Variants in Mediating Risk for Brain Developmental Disorders: Evidence From 20-Year Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewPatients with congenital heart disease (CHD) suffer from a pattern of neurodevelopmental abnormalities including deficits in language and executive function. In this review, we summarize recent studies that examine these outcomes, their risk factors, possible biomarkers, and attempts to develop therapeutic interventions. RECENT
findingsThe latest literature has highlighted the role of genetics in determining neurologic prognosis, as we have increased our understanding of potentially modifiable perioperative risk factors. The role of potentially neurotoxic medical therapies has become more salient. One recent focus has been how neurodevelopment affects quality of life and leads to a high prevalence of mental illness. Neuroimaging advances have provided new insights into the pathogenesis of deficits. SUMMARY: Although many risk factors in CHD are not modifiable, there is promise for interventions to improve neurodevelopmental outcomes in patients with CHD. Biomarkers are needed to better understand the timing and prognosis of injury and to direct therapy. Research into psychosocial interventions is urgently needed to benefit the many survivors with CHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.