Evidence map›Paper›PMID 31693434›Full record

ArticleJournal of neurophysiology2020

Temporal but not spatial dysmetria relates to disease severity in FA.

Manuela Corti, Agostina Casamento-Moran, Stefan Delmas, Samantha Bracksieck, Jessica Bowman, Blake Meyer, Samantha Norman, Sub Subramony, Evangelos A Christou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Manuela CortiCollege of Medicine, Department of Pediatrics, University of Florida, Gainesville, Florida.
Agostina Casamento-MoranCollege of Health and Human Performance, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Stefan DelmasCollege of Health and Human Performance, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Samantha BracksieckCollege of Health and Human Performance, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Jessica BowmanCollege of Medicine, Department of Pediatrics, University of Florida, Gainesville, Florida.
Blake MeyerCollege of Medicine, Department of Pediatrics, University of Florida, Gainesville, Florida.
Samantha NormanCollege of Medicine, Department of Pediatrics, University of Florida, Gainesville, Florida.
Sub SubramonyCollege of Medicine, Department of Neurology, University of Florida, Gainesville, Florida.
Evangelos A ChristouCollege of Health and Human Performance, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
University of Florida · US

Funding

Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
NICHD NIH HHS T32 HD043730
6 · The paper itself

Abstract

Friedreich's ataxia (FA) is an inherited disease that causes degeneration of the nervous system. Features of FA include proprioceptive and cerebellar deficits leading to impaired muscle coordination and, consequently, dysmetria in force and time of movement. The aim of this study is to characterize dysmetria and its association to disease severity. Also, we examine the neural mechanisms of dysmetria by quantifying the EMG burst area, duration, and time-to-peak of the agonist muscle. Twenty-seven individuals with FA and 13 healthy controls (HCs) performed the modified Functional Ataxia Rating Scale and goal-directed movements with the ankle. Dysmetria was quantified as position and time error during dorsiflexion. FA individuals exhibited greater time but not position error than HCs. Moreover, time error correlated with disease severity and was related to increased agonist EMG burst. Temporal dysmetria is associated to disease severity, likely due to altered activation of the agonist muscle.

Indexed as

AdolescentAdultChildElectromyographyFemaleFootFriedreich AtaxiaHumansMaleMiddle AgedMotor ActivityMuscle, SkeletalSeverity of Illness IndexTime FactorsYoung AdultdysmetriaEMGFriedreich’s ataxia

Identifiers

PMID31693434
PMCPMC8091932
OpenAlexW2983687822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.