Evidence map›Paper›PMID 31693432›Full record

ArticleMolecular biology of the cell2019

Arf-GEF localization and function at myosin-rich adherens junctions via coiled-coil heterodimerization with an adaptor protein.

Shiyu Zheng, Junior J West, Cao Guo Yu, Tony J C Harris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Planar Cell Polarity and E-Cadherin in Tissue-Scale Shape Changes inFrontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shiyu ZhengDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
Junior J WestDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
Cao Guo YuDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
Tony J C HarrisDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.ORCID 0000-0002-0798-970X

Funding

CIHR
6 · The paper itself

Abstract

Tissue dynamics require regulated interactions between adherens junctions and cytoskeletal networks. For example, myosin-rich adherens junctions recruit the cytohesin Arf-GEF Steppke, which down-regulates junctional tension and facilitates tissue stretching. We dissected this recruitment mechanism with structure-function and other analyses of Steppke and Stepping stone, an implicated adaptor protein. During

Indexed as

ActomyosinAdaptor Proteins, Signal TransducingAdherens JunctionsAnimalsCytoskeletonDrosophila melanogasterDrosophila ProteinsEpitheliumGuanine Nucleotide Exchange FactorsHydrophobic and Hydrophilic InteractionsProtein DomainsStructure-Activity RelationshipActomyosinAdaptor Proteins, Signal TransducingDrosophila ProteinsGuanine Nucleotide Exchange FactorsSstn protein, DrosophilaStep protein, Drosophila

Identifiers

PMID31693432
PMCPMC6938242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.