Evidence map›Paper›PMID 31693428›Full record

ArticleJournal of neurophysiology2019

Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington's disease mice.

Ana María Estrada-Sánchez, Courtney L Blake, Scott J Barton, Andrew G Howe, George V Rebec

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ana María Estrada-SánchezProgram in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Courtney L BlakeProgram in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Scott J BartonProgram in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Andrew G HoweNeuroscience Interdepartmental Program, University of California, Los Angeles, California.
George V RebecProgram in Neuroscience and Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Indiana University Bloomington · USUniversity of California, Los Angeles · US

Funding

Training Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4M
NINDS NIH HHS T32 NS058280
6 · The paper itself

Abstract

Abnormal communication between cerebral cortex and striatum plays a major role in the motor symptoms of Huntington's disease (HD), a neurodegenerative disorder caused by a mutation of the huntingtin gene (

Indexed as

AnimalsBehavior, AnimalBrain WavesDisease Models, AnimalFemaleHuntingtin ProteinHuntington DiseaseMaleMaze LearningMiceMice, TransgenicMotor CortexNeostriatumNerve NetHtt protein, mouseHuntingtin ProteinBACHD micedorsal striatumlocal field potentialsM1 cortexmotor inflexibility

Identifiers

PMID31693428
PMCPMC6966319
OpenAlexW2982723386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.