ArticleAmerican journal of physiology. Cell physiology2020
Dysregulation of the glutaredoxin/
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Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- The Iron Lung: Ferroptosis and Iron Regulation in Aging and Lung Diseases.Physiology (Bethesda, Md.) · 2027Review
- Glutathione Biology in Neurodegenerative and Metabolic Diseases: Molecular Mechanisms, Pathophysiological Roles, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Organ-specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides.FEBS letters · 2026Article
- Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.American journal of physiology. Cell physiology · 2026Article
- Sputum Glutaredoxin 1 and Protein S-Glutathionylation in COPD.Antioxidants (Basel, Switzerland) · 2026Article
- Genome-wide identification and expression analysis under selenium stress of glutaredoxin system genes in Cardamine hupingshanensis.BMC plant biology · 2026Article
- The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors.Genes & diseases · 2025Review
- Endoplasmic Reticulum Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation.American journal of respiratory cell and molecular biology · 2024Article
- The association between cumulative exposure to PMRespiratory research · 2024Article
- Glutathione dynamics in subcellular compartments and implications for drug development.Current opinion in chemical biology · 2024Review
- Glutaredoxin 2 Protein (Grx2) as an Independent Prognostic Factor Associated with the Survival of Colon Adenocarcinoma Patients.International journal of molecular sciences · 2024Article
- Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system xScience advances · 2023Article
- Chemistry and biology of enzymes in protein glutathionylation.Current opinion in chemical biology · 2023Review
- Low-dose vanadium pentoxide perturbed lung metabolism associated with inflammation and fibrosis signaling in male animal and in vitro models.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility.Nature communications · 2023Article
- Review
- Cysteine residues in signal transduction and its relevance in pancreatic beta cells.Frontiers in endocrinology · 2023Review
- The impact of bacterial exposure in early life on lung surfactant gene expression, function and respiratory rate in germ-free mice.Frontiers in microbiomes · 2023Article
- Emerging chemistry and biology in protein glutathionylation.Current opinion in chemical biology · 2022Review
- Defining the S-Glutathionylation Proteome by Biochemical and Mass Spectrometric Approaches.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Shi B ChiaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Evan A ElkoDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Reem AboushoushaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Allison M ManuelDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Cheryl van de WeteringDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Joseph E DrusoDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Jos van der VeldenDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
David J SewardDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Vikas AnathyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
Charles G IrvinDepartment of Medicine, University of Vermont, Burlington, Vermont.
Ying-Wai LamDepartment of Biology, University of Vermont, Burlington, Vermont.
Albert van der VlietDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.ORCID 0000-0003-0923-0016
Yvonne M W Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont.
University of Vermont · US
Funding
Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4MS-glutathionylation chemistry in fibrotic lung remodelingR35HL135828 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2017 to 2023
$6.5MMultidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1MDual Oxidase in Airway Epithelial Repair and RemodelingR01HL085646 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2008 to 2020
$4.7MMitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6MEndoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5MS-glutathionylation chemistry, glycolysis and obese allergic asthmaR01HL137268 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, VAN DER VLIET, ALBERT · 2017 to 2020
$2.1MDUOX1 and Mitochondria in Obese AsthmaR01HL138708 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2017 to 2020
$2.1MGSTP1-induced S-glutathionylation in lung cancerR01CA219156 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VELDEN, ADRIANUS (JOS)L.J. · 2017 to 2021
$1.8MUnfolded protein response in Influenza virus infection and inflammationR01HL141364 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2019 to 2022
$1.6MDUOX1 Silencing in Age-Related COPDR21AG055325 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2017 to 2018
$429kThe Role of Peroxiredoxin 4 in Idiopathic Pulmonary FibrosisF31HL144051 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ELKO, EVAN · 2019 to 2020
$45kNCI NIH HHS R01 CA219156NHLBI NIH HHS F31 HL144051NHLBI NIH HHS R01 HL085646NHLBI NIH HHS R01 HL122383NHLBI NIH HHS R01 HL136917NHLBI NIH HHS R01 HL137268NHLBI NIH HHS R01 HL138708NHLBI NIH HHS R01 HL141364NHLBI NIH HHS R35 HL135828NHLBI NIH HHS T32 HL076122NIA NIH HHS R21 AG055325NIGMS NIH HHS P20 GM103449
Abstract
Glutathione is a major redox buffer, reaching millimolar concentrations within cells and high micromolar concentrations in airways. While glutathione has been traditionally known as an antioxidant defense mechanism that protects the lung tissue from oxidative stress, glutathione more recently has become recognized for its ability to become covalently conjugated to reactive cysteines within proteins, a modification known as
Indexed as
Amino Acid SequenceAnimalsAntioxidantsCysteineDisulfidesGlutaredoxinsGlutathioneHumansLungLung DiseasesMiceMice, Inbred BALB COxidation-ReductionOxidative StressAntioxidantsCysteineDisulfidesGLRX protein, humanGlutaredoxinsGlutathioneallergic airway diseaseasthmachronic obstructive pulmonary diseasefibrosisglutaredoxinglutathiolationglutathioneglutathione S-transferaseglutathionylation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.