Evidence map›Paper›PMID 31693003›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2012

Probing the interior of synaptic vesicles with internalized nanoparticles.

Jennifer C Gadd, Kristi L Budzinski, Yang-Hsiang Chan, Fangmao Ye, Daniel T Chiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jennifer C GaddDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Kristi L BudzinskiDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Yang-Hsiang ChanDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Fangmao YeDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Daniel T ChiuDepartment of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.

Funding

Single-Molecule Studies of Synaptic VesiclesR01NS062725 · NINDS · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T · 2008 to 2011
$1.3M
NINDS NIH HHS R01 NS062725
6 · The paper itself

Abstract

Synaptic vesicles are subcellular organelles that are found in the synaptic bouton and are responsible for the propagation of signals between neurons. Synaptic vesicles undergo endo- and exocytosis with the neuronal membrane to load and release neurotransmitters. Here we discuss how we utilize this property to load nanoparticles as a means of probing the interior of synaptic vesicles. To probe the intravesicular region of synaptic vesicles, we have developed a highly sensitive pH-sensing polymer dot. We feel the robust nature of the pH-sensing polymer dot will provide insight into the dynamics of proton loading into synaptic vesicles.

Indexed as

Förster resonance energy transfer (FRET)pH sensorpolymer dotssingle moleculesynaptic vesiclessynaptosome

Identifiers

PMID31693003
PMCPMC6830725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.