Evidence map›Paper›PMID 31692977›Full record

ArticleWorld journal of stem cells2019

Stem cell treatment and cerebral palsy: Systemic review and meta-analysis.

Simone Eggenberger, Céline Boucard, Andreina Schoeberlein, Raphael Guzman, Andreas Limacher, Daniel Surbek, Martin Mueller

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of stem cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05293873 (Outcomes of Autologous Bone Marrow-derived Mononuclear Cell Transplantation in the Management of Neurological Sequelae After Traumatic Brain Injury), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05293873 phase1 / phase2completednot on this mapstarted 2021, after this paper: background citation

Outcomes of Autologous Bone Marrow-derived Mononuclear Cell Transplantation in the Management of Neurological Sequelae After Traumatic Brain Injury

TypeinterventionalSponsorVinmec Research Institute of Stem Cell and Gene TechnologyRan2021 to 2023Enrolled50ConditionsSequelae of Injuries of HeadArmsautologous bone marrow-derived mononuclear cell transplantation, Rehabilitation therapy
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  19. Mesenchymal stem cells and cerebral palsy.Journal of the Chinese Medical Association : JCMA · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Simone EggenbergerDepartment of Obstetrics and Gynaecology, Inselspital, University Hospital Bern, Bern 3010, Switzerland.
Céline BoucardDepartment for BioMedical Research, University of Bern, Bern 3008, Switzerland.
Andreina SchoeberleinDepartment for BioMedical Research, University of Bern, Bern 3008, Switzerland.
Raphael GuzmanDepartment of Neurosurgery, University Hospital of Basel, Basel 4056, Switzerland.
Andreas LimacherCTU Bern, University of Bern, Bern 3012, Switzerland.
Daniel SurbekDepartment of Obstetrics and Gynaecology, Inselspital, University Hospital Bern, Bern 3010, Switzerland.
Martin MuellerDepartment of Obstetrics and Gynaecology, Inselspital, University Hospital Bern, Bern 3010, Switzerland.
University Hospital of Bern · CHUniversity of Bern · CHUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerinatal complications may result in life-long morbidities, among which cerebral palsy (CP) is the most severe motor disability. Once developed, CP is a non-progressive disease with a prevalence of 1-2 per 1000 live births in developed countries. It demands an extensive and multidisciplinary care. Therefore, it is a challenge for our health system and a burden for patients and their families. Recently, stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.

aimThe aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis.

methodsWe performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials (RCT) investigating the effect of stem cell transplantation in children with CP. After the review, we performed a random-effects meta-analysis focusing on the change in gross motor function, which was quantified using the gross motor function measure. We calculated the pooled standardized mean differences of the 6- and/or 12-mo-outcome by the method of Cohen. We quantified the heterogeneity using the I-squared measure.

resultsWe identified a total of 8 RCT for a qualitative review. From the initially selected trials, 5 met the criteria and were included in the meta-analysis. Patients' population ranged from 0.5 up to 35 years (

conclusionStem cell therapy for CP compared with symptomatic standard care only, shows a significant positive effect on the gross motor function, although the magnitude of the improvement is limited. Short-term safety is present and further high-quality RCTs are needed.

Indexed as

Cerebral palsyGross motor functionMesenchymal stem/stromal cellsMeta-analysisPerinatal brain injuryStem cellsUmbilical cord blood

Identifiers

PMID31692977
PMCPMC6828595
OpenAlexW2980875245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.