Evidence map›Paper›PMID 31692828›Full record

ArticleThe Pan African medical journal2019

Tuberculosis and HIV co-infection in Congolese children: risk factors of death.

Olivier Mukuku, Augustin Mulangu Mutombo, Christian Ngama Kakisingi, Jacques Mbaz Musung, Stanislas Okitotsho Wembonyama, Oscar Numbi Luboya

Open access · goldAbstract read
In one paragraph

Article in The Pan African medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Olivier MukukuDepartment of Research, Institut Supérieur des Techniques Médicales, Lubumbashi, Democratic Republic of Congo.
Augustin Mulangu MutomboDepartment of Pediatrics, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.
Christian Ngama KakisingiDepartment of Internal Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.
Jacques Mbaz MusungDepartment of Internal Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.
Stanislas Okitotsho WembonyamaDepartment of Pediatrics, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo.
Oscar Numbi LuboyaDepartment of Research, Institut Supérieur des Techniques Médicales, Lubumbashi, Democratic Republic of Congo.
University of Lubumbashi · CD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman immunodeficiency virus (HIV) and tuberculosis (TB) are the leading causes of death from infectious disease worldwide. The prevalence of HIV among children with TB in moderate to high prevalence countries ranges between 10% and 60%. This study aimed to determine the prevalence of HIV infection among children treated for TB in Directly Observed Treatment Short-Course (DOTS) clinics in Lubumbashi and to identify risk of death during this co-infection.

methodsThis is a cross-sectional study of children under-15, treated for tuberculosis from January 1, 2013 to December 31, 2015. Clinical, paraclinical and outcome data were collected in 22 DOTS of Lubumbashi. A statistical comparison was made between dead and survived HIV-infected TB children. We performed the multivariate analyzes and the significance level set at p-value <0.05.

resultsA total of 840 children with TB were included. The prevalence of HIV infection was 20.95% (95% CI: 18.34-23.83%). The mortality rate was higher for HIV-infected children (47.73%) compared to HIV-uninfected children (17.02%) (p<0.00001). Age <5 years (aOR=6.50 [1.96-21.50]), a poor nutritional status (aOR=23.55 [8.20-67.64]), and a negative acid-fast bacilli testing (aOR=4.51 [1.08-18.70]) were associated with death during anti-TB treatment.

conclusionTB and HIV co-infection is a reality in pediatric settings in Lubumbashi. High mortality highlights the importance of early management.

Indexed as

Nutritional StatusAntitubercular AgentsChildChild, PreschoolCoinfectionCross-Sectional StudiesDemocratic Republic of the CongoDirectly Observed TherapyFemaleHIV InfectionsHumansMalePrevalenceRisk FactorsTuberculosisAntitubercular AgentsChildCo-infectionHIVLubumbashiMortalityTuberculosis

Identifiers

PMID31692828
PMCPMC6815491
OpenAlexW2970197930

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.