Evidence map›Paper›PMID 31692772›Full record

ArticleOncotarget2019

The predictive capability of immunohistochemistry and DNA sequencing for determining

Aarash K Roshandel, Christopher M Busch, Jennifer Van Mullekom, Joshua A Cuoco, Cara M Rogers, Lisa S Apfel, Eric A Marvin, Harald W Sontheimer, Robyn A Umans

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The Pathology according to p53 Pathway.Pathobiology : journal of immunopathology, molecular and cellular biology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. OncoTargets and therapy · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aarash K Roshandel *College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Christopher M Busch *The Fralin Biomedical Research Institute at VTC, Roanoke, VA 24016, USA.
Jennifer Van MullekomDepartment of Statistics (MC0439), Hutcheson Hall, Blacksburg, VA 24061, USA.
Joshua A CuocoCarilion Clinic, Division of Neurosurgery, Roanoke, VA 24014, USA.
Cara M RogersVirginia Tech School of Neuroscience, Blacksburg, VA 24061, USA.
Lisa S ApfelVirginia Tech School of Neuroscience, Blacksburg, VA 24061, USA.
Eric A MarvinVirginia Tech School of Neuroscience, Blacksburg, VA 24061, USA.
Harald W SontheimerThe Fralin Biomedical Research Institute at VTC, Roanoke, VA 24016, USA.
Robyn A UmansThe Fralin Biomedical Research Institute at VTC, Roanoke, VA 24016, USA.
Edward Via College of Osteopathic Medicine · USVirginia Tech · USBiomedical Research Institute · US

Funding

Amino Acid Transport and the Biology of Human GliomasR01NS052634 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2005 to 2015
$3.7M
Regulation of Amino-acid Transport in Human GliomasR01CA227149 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA227149NINDS NIH HHS R01 NS052634
6 · The paper itself

Abstract

Tumor protein 53 (p53) regulates fundamental pathways of cellular growth and differentiation. Aberrant p53 expression in glioblastoma multiforme, a terminal brain cancer, has been associated with worse patient outcomes and decreased chemosensitivity. Therefore, correctly identifying p53 status in glioblastoma is of great clinical significance. p53 immunohistochemistry is used to detect pathological presence of the

Indexed as

gene sequencingglioblastoma multiformeimmunohistochemistryp53TP53

Identifiers

PMID31692772
PMCPMC6817445
OpenAlexW2984488574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.