Evidence map›Paper›PMID 31692665›Full record

ArticleAnnals of medicine and surgery (2012)2019

Usefulness of serum Mac-2 binding protein glycosylation isomer in patients undergoing hepatectomy: A case controlled study.

Masahide Hiyoshi, Koichi Yano, Atsushi Nanashima, Makoto Ikenoue, Naoya Imamura, Yoshiro Fujii, Takeomi Hamada, Takahiro Nishida

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Article in Annals of medicine and surgery (2012), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Masahide HiyoshiDivision of Hepato-biliary-pancreatic Surgery and Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Koichi YanoDivision of Hepato-biliary-pancreatic Surgery and Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Atsushi NanashimaDivision of Hepato-biliary-pancreatic Surgery and Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Makoto IkenoueDivision of Gastrointestinal, Endocrine and Pediatric Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Naoya ImamuraDivision of Hepato-biliary-pancreatic Surgery and Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Yoshiro FujiiDivision of Hepato-biliary-pancreatic Surgery and Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Takeomi HamadaDivision of Hepato-biliary-pancreatic Surgery and Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.
Takahiro NishidaDivision of Gastrointestinal, Endocrine and Pediatric Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the clinical significance of Mac-2 binding protein glycosylation isomer (M2BPGi), we investigated the relationship between M2BPGi and clinicopathological and surgical parameters and posthepatectomy complications. MATERIALS AND

methodsWe examined M2BPGi in 115 patients with hepatic malignancies undergoing hepatectomy. Significance as an independent prognostic marker was determined with multivariate logistic regression analysis.

resultsThe mean serum M2BPGi level was 1.14 ± 1.03 C.O.I. (range 0.2-5.79). M2BPGi in the chronic viral hepatitis group (1.42 ± 1.25) was significantly higher than that in the other disease groups (p < 0.05). The M2BPGi level correlated negatively with platelet count, LHL15 and GSA-Rmax (r = -0.36, -0.69 and -0.56, respectively; p < 0.01) but correlated positively with serum hyaluronate level (fibrotic marker), ICGR15 and HH15 (r = 0.52, 0.63 and 0.57, respectively; p < 0.01). In 53 patients examined for histological hepatic fibrosis, the M2BPGi level was highest for hepatic fibrosis stage 4, indicating cirrhosis (2.15 ± 1.56), and was significantly higher than that for stages 0-2 (p < 0.05). M2BPGi level did not correlate significantly with any surgical parameters. The preoperative level correlated significantly only with increased alanine aminotransferase level (r = -0.21, p < 0.05) and was significantly higher in patients with (1.35 ± 0.78) than without (1.11 ± 1.07) hepatectomy-related complications (p < 0.05). Area under the ROC curve analysis for prediction of hepatic fibrosis score 4 showed a cut-off value of 0.78 for M2BPGi to have high sensitivity (90%) and specificity (58%). For postoperative hepatectomy-related complications, only the M2BPGi level (at a cut-off value 0.90) tended to show significance (p = 0.06).

conclusionsThe non-invasively measured serum level of M2BPGi reflected impaired liver function or cirrhosis and hepatectomy-related complications after surgery, making it potentially useful as a complementary parameter accompanying other liver function parameters.

Indexed as

HepatectomyHepatic fibrosisMac-2 binding protein glycosylation isomer (M2BPGi)Morbidity

Identifiers

PMID31692665
PMCPMC6806367

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