ArticleActa crystallographica. Section D, Structural biology2019
Visualization of protein crystals by high-energy phase-contrast X-ray imaging.
Article in Acta crystallographica. Section D, Structural biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Convergent-beam X-ray crystallography.Journal of applied crystallography · 2026Article
- Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis.Science advances · 2026Article
- Current and future perspectives for structural biology at the Grenoble EPN campus: a comprehensive overview.Journal of synchrotron radiation · 2025Review
- Article
- High Throughput Tomography (HiTT) on EMBL beamline P14 on PETRA III.Journal of synchrotron radiation · 2024Article
- Towards virtual histology with X-ray grating interferometry.Scientific reports · 2023Article
- Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- X-ray tomographic reconstruction and segmentation pipeline for the long-wavelength macromolecular crystallography beamline at Diamond Light Source.Journal of synchrotron radiation · 2021Article
- Low-doseIUCrJ · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
For the extraction of the best possible X-ray diffraction data from macromolecular crystals, accurate positioning of the crystals with respect to the X-ray beam is crucial. In addition, information about the shape and internal defects of crystals allows the optimization of data-collection strategies. Here, it is demonstrated that the X-ray beam available on the macromolecular crystallography beamline P14 at the high-brilliance synchrotron-radiation source PETRA III at DESY, Hamburg, Germany can be used for high-energy phase-contrast microtomography of protein crystals mounted in an optically opaque lipidic cubic phase matrix. Three-dimensional tomograms have been obtained at X-ray doses that are substantially smaller and on time scales that are substantially shorter than those used for diffraction-scanning approaches that display protein crystals at micrometre resolution. Adding a compound refractive lens as an objective to the imaging setup, two-dimensional imaging at sub-micrometre resolution has been achieved. All experiments were performed on a standard macromolecular crystallography beamline and are compatible with standard diffraction data-collection workflows and apparatus. Phase-contrast X-ray imaging of macromolecular crystals could find wide application at existing and upcoming low-emittance synchrotron-radiation sources.
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Registered trials
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