Evidence map›Paper›PMID 31692133›Full record

ArticleAddiction (Abingdon, England)2020

Maternal and infant characteristics associated with maternal opioid overdose in the year following delivery.

Timothy Nielsen, Dana Bernson, Mishka Terplan, Sarah E Wakeman, Amy M Yule, Pooja K Mehta, Monica Bharel, Hafsatou Diop, Elsie M Taveras, Timothy E Wilens and 1 more

Open access · greenAbstract read
In one paragraph

Article in Addiction (Abingdon, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

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  3. Hospital Care for Pregnant Persons With OUD Review.American journal of medicine open · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Timothy NielsenMassachusetts Department of Public Health, Boston, MA, USA.
Dana BernsonMassachusetts Department of Public Health, Boston, MA, USA.
Mishka TerplanDepartment of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA, USA.
Sarah E WakemanDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5475-2713
Amy M YuleDivision of Child and Adolescent Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Pooja K MehtaCenter for Healthcare Value and Equity, Department of Obstetrics and Gynecology, and Program in Health Policy and Systems Management, Schools of Medicine and Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Monica BharelMassachusetts Department of Public Health, Boston, MA, USA.
Hafsatou DiopMassachusetts Department of Public Health, Boston, MA, USA.
Elsie M TaverasDivision of General Academic Pediatrics, Massachusetts General Hospital for Children, Boston, MA, USA.
Timothy E WilensDivision of Child and Adolescent Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Davida M SchiffDivision of General Academic Pediatrics, Massachusetts General Hospital for Children, Boston, MA, USA.ORCID 0000-0002-6435-1016
Massachusetts General Hospital · USMassachusetts Department of Public Health · USLouisiana State University Health Sciences Center New Orleans · USThe University of Sydney · AUVirginia Commonwealth University · US

Funding

AACAP Physician Scientist Program in Substance UseK12DA000357 · NIDA · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · PI Kevin M. Gray · 1998 to 2026
$29.1M
Career Development Program in Substance Use and Addiction MedicineK12DA043490 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI A EDEN EVINS, NANCY A RIGOTTI · 2017 to 2026
$4.7M
Mentoring in Addiction Treatment ResearchK24DA030443 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI EVINS, A EDEN · 2010 to 2020
$2.0M
Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant DyadsK23DA048169 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI SCHIFF, DAVIDA · 2019 to 2023
$998k
Patient Oriented Research and Mentorship in Childhood Obesity DisparitiesK24DK105989 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TAVERAS BENAVIDEZ, ELSIE MIREYA · 2015 to 2019
$907k
CDC HHS 1U38OT000143-04NIDA NIH HHS K12 DA000357NIDA NIH HHS K12 DA043490NIDA NIH HHS K23 DA048169NIDA NIH HHS K24 DA030443NIDDK NIH HHS K24 DK105989OSTLTS CDC HHS U38 OT000143
6 · The paper itself

Abstract

BACKGROUND AND

aimsOpioid-related overdose is increasingly linked to pregnancy-associated deaths, but factors associated with postpartum overdose are unknown. We aimed to estimate the strength of the association between maternal and infant characteristics and postpartum opioid-related overdose.

designRetrospective cohort study using a linked, population-level data set.

settingMassachusetts, United States.

conclusionAmong women who delivered live infants in Massachusetts, USA between 2012 and 2014, maternal diagnosis of OUD, prior non-fatal overdose, infant diagnosis of NAS and high unscheduled health-care utilization appeared to be positively associated with postpartum opioid overdose. However, more than half of postpartum overdoses in that period were to women without a diagnosis of OUD. Engagement in methadone or buprenorphine treatment in the month prior to delivery was not sufficient to reduce the odds of postpartum overdose.

participantsWomen who delivered one or more live births from 2012 to 2014 (n = 174 517). MEASUREMENTS: The primary outcome was opioid-related overdose in the postpartum year. We used multivariable logistic regression to explore the independent associations of maternal (demographics, substance use, pregnancy) and infant [gestational age, birthweight, neonatal abstinence syndrome (NAS)] characteristics with postpartum opioid overdose. Findings were stratified by maternal opioid use disorder (OUD) diagnosis.

findingsThere were 189 deliveries to women who experienced ≥ 1 opioid overdose in the first year postpartum (11 of 10 000 deliveries). Among women with postpartum opioid overdose, 46.6% had an OUD diagnosis within 12 months before delivery. In our adjusted model, maternal diagnosis of OUD [adjusted odds ratio (aOR) = 3.61, 95% confidence interval (CI) = 1.73-7.51] and prior non-fatal overdose (aOR = 2.40, 95% CI = 1.11-5.17) were most strongly associated with postpartum overdose. After stratifying by OUD status, infant diagnosis of NAS (OUD

Indexed as

Postpartum PeriodAdultCohort StudiesDatasets as TopicFacilities and Services UtilizationFemaleHumansInfantInfant, NewbornInformation Storage and RetrievalLive BirthMassachusettsNeonatal Abstinence SyndromeOpiate OverdoseOpiate Substitution TreatmentOpioid-Related DisordersMaternalneonatal abstinence syndromenon-fatalopioid use disorderoverdosepostpartumpregnancywomen

Identifiers

PMID31692133
PMCPMC7066531
OpenAlexW2983353425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.