Evidence map›Paper›PMID 31691988›Full record

ArticleLipids2020

Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids.

Yurika Otoki, Adam H Metherel, Theresa Pedersen, Jun Yang, Bruce D Hammock, Richard P Bazinet, John W Newman, Ameer Y Taha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Yurika OtokiDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.
Adam H MetherelDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, M5S 1A8, Canada.
Theresa PedersenDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.
Jun YangDepartment of Entomology and Nematology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, 95616, USA.
Bruce D HammockDepartment of Entomology and Nematology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, 95616, USA.
Richard P BazinetDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, M5S 1A8, Canada.
John W NewmanWest Coast Metabolomics Center, Genome Center, University of California-Davis, Davis, CA, 95616, USA.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.
University of California, Davis · USUniversity of Toronto · CATohoku University · JPUniversity of California Davis Medical Center · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
NIDDK NIH HHS U24 DK097154NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710
6 · The paper itself

Abstract

In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating esterified lipids using 100 and 500 mg columns and (2) applied the method to quantify the distribution of esterified oxylipins within phospholipids (PL) and neutral lipids (NL) (i.e. triacylglycerol and cholesteryl ester) in rats subjected to head-focused microwave fixation (controls) or CO

Indexed as

AnimalsArachidonic AcidBrainBrain ChemistryChromatography, High Pressure LiquidDocosahexaenoic AcidsEpoxy CompoundsEsterificationHypercapniaMaleOxylipinsPhospholipidsRatsSolid Phase ExtractionTandem Mass SpectrometryArachidonic AcidDocosahexaenoic AcidsEpoxy CompoundsOxylipinsPhospholipidsArachidonic acid and docosahexaenoic acid epoxidesEicosanoidsEsterified oxylipinsHypercapnia/ischemiaRat brainTurnover

Identifiers

PMID31691988
PMCPMC7220815
OpenAlexW2985288842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.