Evidence map›Paper›PMID 31691846›Full record

ArticlePsychopharmacology2020

Social experience and sex-dependent regulation of aggression in the lateral septum by extrasynaptic δGABA

Johnathan M Borland, James C Walton, Alisa Norvelle, Kymberly N Grantham, Lauren M Aiani, Tony E Larkin, Katharine E McCann, H Elliott Albers

Open access · greenAbstract read
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Sex differences in the neural circuitry of aggression.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. TheFrontiers in psychology · 2024
    Article
  7. Review
  8. Neuroendocrine regulation of female aggression.Frontiers in endocrinology · 2022
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Johnathan M BorlandCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
James C WaltonCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Alisa NorvelleCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Kymberly N GranthamCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Lauren M AianiCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Tony E LarkinCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Katharine E McCannCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
H Elliott AlbersCenter for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA. biohea@gsu.edu.ORCID http://orcid.org/0000-0001-7491-3978
Georgia State University · US

Funding

Sex Differences in the Social BrainR01MH110212 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT, MICHOPOULOS, VASILIKI · 2016 to 2020
$3.3M
Advances in the Study of Social NeuroendocrinologyR21MH109302 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT, HUHMAN, KIM L · 2016 to 2017
$417k
The roles of GABA receptor subunits in circadian rhythms in GABA responsiveness in the suprachiasmatic nucleusF32NS092545 · NINDS · GEORGIA STATE UNIVERSITY · PI WALTON, JAMES C. · 2015 to 2017
$168k
Sex differences in oxytocin modulation of social reward in the mesolimbic dopamine systemF31MH113367 · NIMH · GEORGIA STATE UNIVERSITY · PI BORLAND, JOHNATHAN · 2017 to 2018
$76k
NIMH NIH HHS F31 MH113367NIMH NIH HHS MH110212NIMH NIH HHS R01 MH110212NIMH NIH HHS R21 MH109302NINDS NIH HHS F32 NS092545
6 · The paper itself

Abstract

rationaleUnderstanding the neurobiological mechanisms mediating dominance and competitive aggression is essential to understanding the development and treatment of various psychiatric disorders. Previous research suggests that these mechanisms are both sexually differentiated and influenced substantially by social experience. In numerous species, GABA

objectivesThus, in the following set of experiments, we determined the role of social experience in modulating GABA

resultsActivation of GABA

conclusionsThese data suggest that social experience can have profound effects on the neuronal mechanisms mediating aggression, especially in males, and that δ extrasynaptic GABA

Indexed as

Sex CharacteristicsSocial BehaviorAggressionAnimalsCricetinaeFemaleGABA-A Receptor AgonistsMaleMesocricetusMicroinjectionsNeuronsReceptors, GABA-ASeptal NucleiGABA-A Receptor AgonistsReceptors, GABA-AAgonistic behaviorDominance relationshipsSex differencesSocial behaviorSocial isolationSynaptic γ2GABAA receptors

Identifiers

PMID31691846
PMCPMC7024004
OpenAlexW2986627950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.