Evidence map›Paper›PMID 31691834›Full record

ArticleNucleic acids research2020

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY.

Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Joanna L Sharman, Brice Campo, David R Cavanagh, Stephen P H Alexander, Anthony P Davenport and 3 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed.

  1. Chemogenetic Activation of GFASEB bioAdvances · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The IUPHAR/BPS Guide to PHARMACOLOGY in 2026.Nucleic acids research · 2026
    Article
  6. Loss-of-function GαScience signaling · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Identification of GαScientific reports · 2024
    Article
  11. Article
  12. Article
  13. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024.Nucleic acids research · 2024
    Article
  14. Article
  15. Article
  16. Exploring DrugCentral: from molecular structures to clinical effects.Journal of computer-aided molecular design · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Dopamine Receptor D1 Is Exempt from Transforming Growth FactorThe Journal of pharmacology and experimental therapeutics · 2023
    Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jane F ArmstrongDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Elena FaccendaDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Simon D HardingDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Adam J PawsonDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Christopher SouthanDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Joanna L SharmanDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Brice CampoMedicines for Malaria Venture, Post Box 1826, 1215 Geneva 15, Switzerland.
David R CavanaghInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3FL, UK.
Stephen P H AlexanderSchool of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.
Anthony P DavenportExperimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2 0QQ, UK.
Michael SpeddingSpedding Research Solutions SAS, Le Vésinet 78110, France.
Jamie A DaviesDeanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
NC-IUPHAR

Funding

Wellcome TrustWellcome Trust 108420/Z/15/Z
6 · The paper itself

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe significant updates made over the seven releases during the last two years. The database is notably enhanced through the continued linking of relevant pharmacology with key immunological data types as part of the IUPHAR Guide to IMMUNOPHARMACOLOGY (www.guidetoimmunopharmacology.org) and by a major new extension, the IUPHAR/MMV Guide to Malaria PHARMACOLOGY (www.guidetomalariapharmacology.org). The latter has been constructed in partnership with the Medicines for Malaria Venture, an organization dedicated to identifying, developing and delivering new antimalarial therapies that are both effective and affordable. This is in response to the global challenge of over 200 million cases of malaria and 400 000 deaths worldwide, with the majority in the WHO Africa Region. It provides new pharmacological content, including molecular targets in the malaria parasite, interaction data for ligands with antimalarial activity, and establishes curation of data from screening assays, used routinely in antimalarial drug discovery, against the whole organism. A dedicated portal has been developed to provide quick and focused access to these new data.

Indexed as

Databases, FactualDatabases, PharmaceuticalPharmacologyAntimalarialsDrug DiscoveryHumansLigandsMalariaMolecular Targeted TherapyPlasmodiumSoftwareUser-Computer InterfaceWeb BrowserAntimalarialsLigands

Identifiers

PMID31691834
PMCPMC7145572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.