Evidence map›Paper›PMID 31691723›Full record

Trial reportSao Paulo medical journal = Revista paulista de medicina

Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial.

Sahar Saraf-Bank, Alireza Ahmadi, Zamzam Paknahad, Mohammadreza Maracy, Mojgan Nourian

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Clinical Potential ofFoods (Basel, Switzerland) · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sahar Saraf-BankMSc. Doctoral Student and Dietitian, Students' Research Committee, Isfahan University of Medical Sciences; Doctoral Student and Dietitian, Food Security Research Center, Isfahan University of Medical Sciences; and Doctoral Student and Dietitian, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0003-3443-9559
Alireza AhmadiMD. Associate Professor and Cardiologist, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0002-2462-0162
Zamzam PaknahadPhD. Full Professor and Dietitian, Food Security Research Center, Isfahan University of Medical Sciences, and Full Professor and Dietitian, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0002-1864-2576
Mohammadreza MaracyPhD. Full Professor and Statistician, Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0002-3695-0863
Mojgan NourianPhD. Assistant Professor and Dietitian, Food Security Research Center, Isfahan University of Medical Sciences, and Assistant Professor and Dietitian, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID http://orcid.org/0000-0003-2181-6474
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObese adolescents are at higher risk of development of cardiovascular risk factors and obesity in later life. Dietary intake of antioxidants, particularly curcumin, as an active ingredient of turmeric extract, may have noticeable effects on obesity and its important complications such as cardiovascular risk factors. Therefore, the aim of this study was to assess the effects of curcumin supplementation on cardiovascular risk factors among overweight and obese female adolescents. DESIGN AND

settingRandomized placebo-controlled clinical trial; Pediatric Cardiovascular Research Center, Isfahan, Iran.

methods60 adolescent girls (aged 13-18 years) were randomly assigned to receive either placebo or intervention. The adolescents were asked to consume one 500 mg tablet per day, containing either standardized 95% turmeric extract or placebo, and to undergo a weight maintenance or a mild weight loss diet for 10 weeks. Anthropometric and biochemical indices were assessed at the baseline and the end of the intervention.

resultsCurcumin supplementation had beneficial effects on body mass index (P = 0.019), waist circumference (P = 0.008), hip circumference (P = 0.030), high-density lipoprotein levels (P = 0.042) and triglyceride/high-density lipoprotein ratio (P = 0.021). However, in univariate analysis of covariance, no significant differences were found between the intervention and placebo groups after 10 weeks of supplementation (P > 0.05).

conclusionsPrescription of curcumin supplementation along with use of a slight weight loss diet might have beneficial effects on some cardiovascular risk factors among overweight and obese female adolescents. Larger clinical trials with higher curcumin doses and longer duration are needed to confirm the results from the current study. CLINICAL

trial registrationIRCT20171107037302N1.

Indexed as

AdolescentBlood GlucoseBlood PressureBody CompositionBody Mass IndexCardiovascular DiseasesCardiovascular SystemCurcuminDietary SupplementsDiet, ReducingExerciseFemaleHumansLipidsObesityOverweightBlood GlucoseCurcuminLipids

Identifiers

PMID31691723
PMCPMC9745817
OpenAlexW2984546063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.