ArticleEnvironmental health perspectives2019
Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study.
Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Impacts of heat exposure in utero on long-term health and social outcomes: a systematic review.BMC pregnancy and childbirth · 2024Pooled it
- Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4.Environmental science & technology · 2022Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Association between ambient temperature exposure and pregnancy outcomes in participants undergoing IVF: a retrospective cohort study.Journal of assisted reproduction and genetics · 2026Article
- Windows of susceptibility and joint effects of prenatal and postnatal ambient air pollution and temperature exposure on asthma and wheeze in Mexican children.Environment international · 2024Article
- Association Between Prenatal Exposure to Organochlorine Pesticides and Telomere Length in Neonatal Cord Blood.Toxics · 2024Article
- Prenatal environment impacts telomere length in newborn dairy heifers.Scientific reports · 2023Article
- Interrelationships and determinants of aging biomarkers in cord blood.Journal of translational medicine · 2022Article
- Extreme Heat and Pregnancy Outcomes: A Scoping Review of the Epidemiological Evidence.International journal of environmental research and public health · 2022Article
- Effect of Elevated Ambient Temperature on Maternal, Foetal, and Neonatal Outcomes: A Scoping Review.International journal of environmental research and public health · 2022Article
- Ambient air pollution and low temperature associated with case fatality of COVID-19: A nationwide retrospective cohort study in China.Innovation (Cambridge (Mass.)) · 2021Article
- Different epigenetic signatures of newborn telomere length and telomere attrition rate in early life.Aging · 2021Article
- Hallmarks of environmental insults.Cell · 2021Review
- Educational note: addressing special cases of bias that frequently occur in perinatal epidemiology.International journal of epidemiology · 2021Article
- Association between body temperature and leukocyte telomere length in Korean middle-aged and older adults.Epidemiology and health · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough studies have provided estimates of premature mortality to either heat or cold in adult populations, and fetal exposure to ambient temperature may be associated with life expectancy, the effects of temperature on aging in early life have not yet been studied. Telomere length (TL) is a marker of biological aging, and a short TL at birth may predict lifespan and disease susceptibility later in life.
objectivesWe studied to what extent prenatal ambient temperature exposure is associated with newborn TL.
methodsIn the ENVIR
resultsPrenatal temperature exposure above the heat threshold (19.5°C) was associated with shorter cord blood TL. The association with a 1°C increase in temperature was strongest at week 36 of gestation and resulted in a 3.29% [95% confidence interval (CI): DISCUSSION: Our study supports potential effects of prenatal temperature exposure on longevity and disease susceptibility later in life. Future climate scenarios might jeopardize the potential molecular longevity of future generations from birth onward. https://doi.org/10.1289/EHP5153.
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Registered trials
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