ArticlePhysiological reports2019
Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report.
Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.Artery research · 2026Article
- Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.Research square · 2025Article
- Age alters integrated cerebrovascular and cardiovascular dynamic responses to exercise: insights from a systems modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Feasibility of a Recumbent Stepper for Short-Interval, Low-Volume High-Intensity Interval Exercise in Stroke.Journal of neurologic physical therapy : JNPT · 2025Article
- Middle cerebral artery blood velocity and end-tidal carbon dioxide responses to moderate intensity cycling in children, adolescents, and adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Lower middle cerebral artery blood velocity during low-volume high-intensity interval exercise in chronic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Habitual exercise in youth: A 'brainy' idea.Experimental physiology · 2023Article
- Secondary Analysis of Walking Activities during the Acute Stroke Hospital Stay and Cerebrovascular Health.Cardiopulmonary physical therapy journal · 2022Article
- The effect of exercise intensity and cardiorespiratory fitness on the kinetic response of middle cerebral artery blood velocity during exercise in healthy adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Pilot Study to Characterize Middle Cerebral Artery Dynamic Response to an Acute Bout of Moderate Intensity Exercise at 3- and 6-Months Poststroke.Journal of the American Heart Association · 2021Article
- Chronic hyperglycemia before acute ischemic stroke impairs the bilateral cerebrovascular response to exercise during the subacute recovery period.Brain and behavior · 2021Article
- Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults.Nutrients · 2020Article
- Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: a case report.Physiological reports · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Blood flow regulation is impaired in people with stroke. However, the time course of change in middle cerebral artery velocity (MCAv) following repeated stroke at rest and during exercise remains unknown. In this case study, we provide novel characterization of the dynamic kinetic MCAv response profile to moderate-intensity exercise before and after repeated ischemic MCA stroke. The initial stroke occurred in the left MCA. At 3 months poststroke, left MCAv amplitude (Amp) was ~50% lower than the right. At the 6-month follow-up visit, MCAv Amp declined in both MCA with the left MCAv Amp ~50% lower than the right MCAv Amp. Following a second right MCA stroke, we report further decline in Amp for the left MCA. At the 3- and 6-month visit following the second stroke, the left MCAv Amp declined further (~10%). The right MCAv Amp dramatically decreased by 81.3% when compared to the initial study visit. The MCAv kinetic analysis revealed a marked impairment in the cerebrovascular response to exercise following stroke. We discuss potential pathophysiological mechanisms contributing to poststroke cerebrovascular dysfunction and the need to test therapeutic interventions (such as exercise) that might attenuate cerebrovascular decline in people following stroke.
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