ArticlePhysiological reports2019
Treatment of severe symptomatic hyponatremia.
Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- The risk of sodium overcorrections in severe hyponatremia and the utility of desmopressin: a large retrospective study.Clinical kidney journal · 2025Article
- Article
- Review
- An Uncommon Cause of Choreoathetosis.Journal of the American College of Emergency Physicians open · 2023Article
- Prevalence, Risk Factors, and Mortality of Patients Presenting with Moderate and Severe Hyponatremia in Emergency Departments.Emergency medicine international · 2023Article
- Salt-Losing Syndrome in a Girl with Type I and II Pseudohypoaldosteronism.The American journal of case reports · 2022Article
- Hypertonic Saline for Hyponatremia: Meeting Goals and Avoiding Harm.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Article
- How low can you go? Severe hyponatremia with a sodium of 94 mg/dL corrected with proactive strategy.Journal of community hospital internal medicine perspectives · 2020Article
- Treatment of severe symptomatic hyponatremia.Physiological reports · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia is the most common electrolyte abnormality seen in the hospital. Severe symptomatic hyponatremia is associated with grave consequences including cerebral edema, brain herniation, seizures, obtundation, coma, and respiratory arrest. However, rapid correction of chronic severe hyponatremia may lead to osmotic demyelination syndrome (ODS) and even death. Given the serious consequences of severe hyponatremia or its inadvertent overcorrection, it is of paramount importance for the clinician to be aware of the various scenarios in which hyponatremic patients can present and tailor the management strategies accordingly. We present here a case of severe hyponatremia of unknown duration with the presenting plasma sodium level of 95 mmol/L and use it to illustrate the various treatment strategies - proactive, reactive, or rescue therapy - along with the physiological basis to support these approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.