Evidence map›Paper›PMID 31691371›Full record

ArticleMagnetic resonance in medicine2020

Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner.

Daniel Coman, Dana C Peters, John J Walsh, Lynn J Savic, Steffen Huber, Albert J Sinusas, MingDe Lin, Julius Chapiro, R Todd Constable, Douglas L Rothman and 2 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  14. Imaging Extracellular Acidification and Immune Activation in Cancer.Current opinion in biomedical engineering · 2021
    Article
  15. Article
  16. Article
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  18. Article
  19. Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Daniel ComanDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.ORCID 0000-0002-6289-0817
Dana C PetersDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
John J WalshDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
Lynn J SavicDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
Steffen HuberDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
Albert J SinusasDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
MingDe LinDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.ORCID 0000-0001-7641-2595
Julius ChapiroDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
R Todd ConstableDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
Douglas L RothmanDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
James S DuncanDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
Fahmeed HyderDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, Connecticut.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
NeurophysiologicP30NS052519 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2007 to 2017
$6.7M
Quantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver CancerR01CA206180 · NCI · YALE UNIVERSITY · PI CHAPIRO, JULIUS, DUNCAN, JAMES S · 2016 to 2025
$6.1M
Extracellular pH mapping as therapeutic readout of drug delivery in glioblastomaR01EB023366 · NIBIB · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2017 to 2020
$2.5M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA206180NIBIB NIH HHS R01 EB023366NIGMS NIH HHS T32 GM007205NINDS NIH HHS P30 NS052519
6 · The paper itself

Abstract

purposeTo demonstrate feasibility of developing a noninvasive extracellular pH (pH

methodsIn vivo pH

resultsWe validated BIRDS-based pH in vitro with a pH electrode. We measured pH

conclusionThis work demonstrates feasibility and potential clinical translatability of high-resolution pH

Indexed as

Biosensing TechniquesLiver NeoplasmsAnimalsExtracellular SpaceHydrogen-Ion ConcentrationMagnetic Resonance ImagingRabbitsBIRDSliver cancerMRSpH mappingtumor microenvironmenttumors

Identifiers

PMID31691371
PMCPMC7244229
OpenAlexW2987106767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.