Evidence map›Paper›PMID 31691104›Full record

ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Copper and the brain noradrenergic system.

Svetlana Lutsenko, Clorissa Washington-Hughes, Martina Ralle, Katharina Schmidt

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Copper (CuPharmaceuticals (Basel, Switzerland) · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Copper homeostasis and cuproptosis in Alzheimer's disease (Review).International journal of molecular medicine · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Svetlana LutsenkoDepartment of Physiology, Johns Hopkins Medical Institutes, 725 N Wolfe St, Baltimore, MD, 21205, USA. lutsenko@jhmi.edu.
Clorissa Washington-HughesDepartment of Physiology, Johns Hopkins Medical Institutes, 725 N Wolfe St, Baltimore, MD, 21205, USA.
Martina RalleDepartment of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR, 97329, USA.
Katharina SchmidtDepartment of Physiology, Johns Hopkins Medical Institutes, 725 N Wolfe St, Baltimore, MD, 21205, USA.
Johns Hopkins University · USOregon Health & Science University · US

Funding

Integrative Analysis of Wilson's DiseaseR01GM101502 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LUTSENKO, SVETLANA · 2012 to 2021
$3.6M
NIGMS NIH HHS R01 GM101502NIGMS NIH HHS R01 GM101502-S1
6 · The paper itself

Abstract

Copper (Cu) plays an essential role in the development and function of the brain. In humans, genetic disorders of Cu metabolism may cause either severe Cu deficiency (Menkes disease) or excessive Cu accumulation (Wilson disease) in the brain tissue. In either case, the loss of Cu homeostasis results in catecholamine misbalance, abnormal myelination of neurons, loss of normal brain architecture, and a spectrum of neurologic and/or psychiatric manifestations. Several metabolic processes have been identified as particularly sensitive to Cu dis-homeostasis. This review focuses on the role of Cu in noradrenergic neurons and summarizes the current knowledge of mechanisms that maintain Cu homeostasis in these cells. The impact of Cu misbalance on catecholamine metabolism and functioning of noradrenergic system is discussed.

Indexed as

Adrenergic NeuronsAnimalsCatecholaminesCopperHomeostasisHumansIon TransportLocus CoeruleusCatecholaminesCopperCatecholaminesCopperDopamine-β-hydroxylaseLocus coeruleus

Identifiers

PMID31691104
PMCPMC6941745
OpenAlexW2986708361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.