Evidence map›Paper›PMID 31691067›Full record

ArticleJournal of thrombosis and thrombolysis2020

Platelet reactivity in patients with chronic kidney disease and hemodialysis.

Philipp Mourikis, Carolin Helten, Lisa Dannenberg, Thomas Hohlfeld, Johannes Stegbauer, Tobias Petzold, Bodo Levkau, Tobias Zeus, Malte Kelm, Amin Polzin

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Philipp MourikisDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany.
Carolin HeltenDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany.
Lisa DannenbergDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany.
Thomas HohlfeldInstitute for Pharmacology and Clinical Pharmacology, Heinrich Heine University, Dusseldorf, Germany.
Johannes StegbauerDivision of Nephrology, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany.
Tobias PetzoldMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians- University Munich, München, Germany.
Bodo LevkauInstitute of Pathophysiology, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Tobias ZeusDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany.
Malte KelmDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany.
Amin PolzinDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany. amin.polzin@med.uni-duesseldorf.de.
Heinrich Heine University Düsseldorf · DEDüsseldorf University Hospital · DELudwig-Maximilians-Universität München · DEUniversity of Duisburg-Essen · DE

Funding

Deutsche Forschungsgemeinschaft PO 2247/1-1Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf 16-2014Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf 46-2016
6 · The paper itself

Abstract

End stage renal disease requiring hemodialysis (HD) is frequent and coronary artery disease (CAD) is a common comorbidity. It is associated with bleeding and ischemic events. Platelet reactivity is a well-known determinant of both. However, the impact of HD due to end stage chronic kidney disease (CKD) on platelet reactivity is unknown. Therefore in this study, we evaluated platelet reactivity during hemodialysis in patients with CKD and coronary artery disease. 22 patients with CKD, HD and CAD were included in this study. Light transmission aggregometry (LTA) and flow cytometry were used for evaluating platelet function immediately before and 2 h after initiation of HD. Arachidonic acid-induced maximum of aggregation (MoA

Indexed as

HemorrhagePlatelet ActivationRenal DialysisRenal Insufficiency, ChronicBlood PlateletsFemaleHumansMaleMiddle AgedAggregationChronic kidney diseaseCoronary artery diseaseHemodialysisPlatelets

Identifiers

PMID31691067
OpenAlexW2982757359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.