Evidence map›Paper›PMID 31691046›Full record

ArticleJournal of anesthesia2020

An endotracheal tube providing "pressurized sealing" prevents fluid leakage in mechanically ventilated critically ill patients: a pilot study.

Herbert Spapen, Emiel Suys, Jouke De Regt, Joris Troubleyn, Joop Jonckheer, Elisabeth De Waele

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Herbert SpapenIntensive Care Department, University Hospital Brussels, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium. herbert.spapen@uzbrussel.be.ORCID 0000-0002-7724-886X
Emiel SuysIntensive Care Department, University Hospital Brussels, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.
Jouke De RegtIntensive Care Department, University Hospital Brussels, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.
Joris TroubleynIntensive Care Department, University Hospital Brussels, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.
Joop JonckheerIntensive Care Department, University Hospital Brussels, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.
Elisabeth De WaeleIntensive Care Department, University Hospital Brussels, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.
Vrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microaspiration of bacteriologically contaminated oropharyngeal secretions alongside the cuff of an endotracheal tube (ETT) is a key mechanism for development of ventilator-associated pneumonia. We have constructed a prototype double-cuffed ETT equipped with a supplemental port in-between the cuffs through which continuous positive airway pressure (CPAP) is delivered. Pressure in the intercuff space propels secretions upwards and produces 100% tracheal sealing in an in vitro model. We conducted a 24 h study to investigate the sealing effect of this ETT in 12 critically ill mechanically ventilated patients. Methylene blue, instilled through a bronchoscope on top of the proximal cuff, was used as leakage tracer. Fiberoptic visualisation of the trachea was performed 1 h and 24 h thereafter. Leakage was confirmed if blue dye was detected on the tracheal mucosa beyond the tip of the ETT. In no patient, dye passed by the cuffs during the study period. Presence of the ETT did not interfere with ventilator settings, patient mobilization, physiotherapy, and technical acts. Overall, pressures in the intercuff space remained between 10 and 15 cmH

Indexed as

Critical IllnessRespiration, ArtificialEquipment DesignHumansIntubation, IntratrachealPilot ProjectsCritically illCuffDouble-cuffedEndotracheal tubeLeakageMechanical ventilationMicroaspirationVentilator-associated pneumonia

Identifiers

PMID31691046
PMCPMC7224017
OpenAlexW2985526573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.