Evidence map›Paper›PMID 31691036›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2020

Combination of L1 methylation and tumor-infiltrating lymphocytes as prognostic marker in advanced gastric cancer.

Younghoon Kim, Ye-Young Rhee, Xianyu Wen, Nam-Yun Cho, Jeong Mo Bae, Woo Ho Kim, Gyeong Hoon Kang

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. The oncogenic role of hypomethylated ZNF793 in gastric carcinoma: a focus on cell survival and stemness.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Article
  3. Review
  4. Immunology and immunotherapy in gastric cancer.Clinical and experimental medicine · 2023
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Younghoon KimDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Ye-Young RheePathology Center, Seegene Medical Foundation, Seoul, Korea.
Xianyu WenGuangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Nam-Yun ChoLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Jeong Mo BaeDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Woo Ho KimDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Gyeong Hoon KangDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea. ghkang@snu.ac.kr.
Seoul National University · KRSixth Affiliated Hospital of Sun Yat-sen University · CN

Funding

Korea National Institute of Health HI14C1277Ministry of Education, Science and Technology 2016M3A9B6026921Seegene Medical Foundation 2019-001Seoul National University Hospital 0420180210 (2018-1212)
6 · The paper itself

Abstract

backgroundHigh density of tumor-infiltrating lymphocyte (TIL) is known to be associated with prolonged survival time, whereas tumoral-L1 hypomethylation has been associated with shortened survival time in patients with gastric cancer (GC). Since L1-methylation level is high in lymphocytes, higher density of TIL could lead to higher measurement of L1-methylation level in cancer tissues which contain cancer cells as well as non-neoplastic cells, including TIL. Putative interaction of TIL in the relationship between L1-methylation level and survival led us to explore combinatory statuses of tumoral-L1-methylation level and TIL density as a prognostic marker in GC.

methodsTIL and tumoral-L1-methylation level were measured in advanced GC samples (n = 491), using CD3 immunohistochemistry and pyrosequencing-methylation analysis, respectively. TIL density was measured in tumor center and invasive front areas.

resultsTIL density correlated with tumoral-L1-methylation level but the relationship was weak. Combinatory statuses of L1-methylation level and CD3 TIL density were found to be statistically significant in survival analysis. Multivariate analysis revealed that the relationship between combinatory statuses and survival was independent. Prognostic value of the combinatory statuses at invasive front was significant in an independent set.

conclusionsOur findings indicate that tumoral-L1-methylation level is correlated with TIL density and that combinatory statuses might help to find a subset of GCs with worse clinical outcome in GCs with low-L1-methylation status or a subset of GCs with better clinical outcome in GCs with high-L1-methylation status.

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticLong Interspersed Nucleotide ElementsAdenocarcinomaBiomarkers, TumorFemaleFollow-Up StudiesHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm InvasivenessPrognosisStomach NeoplasmsSurvival RateBiomarkers, TumorGastric cancerL1 elementPrognosisT lymphocyte

Identifiers

PMID31691036
OpenAlexW2985126132

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.