SynthesisJournal of neurology2020
Silent brain infarctions and cognition decline: systematic review and meta-analysis.
Synthesis in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Systematic review of neuroimaging findings in children and young adults with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Intensive Blood Pressure Treatment and Subclinical Brain Infarcts: A Secondary Analysis of SPRINT (Systolic Pressure Intervention Trial).Annals of neurology · 2024Trial
- Predictors of Early Infarct Recurrence in Patients With Symptomatic Intracranial Atherosclerotic Disease.Stroke · 2021Trial
- Cognitive decline and risk of stroke in older women: a cohort study.BMC geriatrics · 2026Article
- Technique and device specific diffusion-weighted imaging detected ischemic lesions and occlusion outcomes in endovascular treatment of unruptured aneurysms.Acta neurochirurgica · 2026Article
- Cognitive decline and risk of all-cause mortality in older women: a cohort study.BMC geriatrics · 2026Article
- Silent brain infarcts after major cardiac interventions: a retrospective paired cohort study using high-resolution DW-MRI.BMC cardiovascular disorders · 2026Article
- The potential value of serum neuron-specific enolase in screening for silent cerebral infarction following radiofrequency catheter ablation for atrial fibrillation.BMC cardiovascular disorders · 2026Article
- A multi-parameter predictive model incorporating VEGF for asymptomatic cerebral infarction after RFCA in atrial fibrillation.Frontiers in cardiovascular medicine · 2026Article
- Role of light transmission aggregometry in predicting diffusion-weighted imaging lesions after stent-assisted coil embolization for intracranial aneurysms: a retrospective propensity score-matched study.Frontiers in neurology · 2026Article
- Hydrophilic Polymer Embolism and Silent Brain Injury: An Underexplored Connection.Cardiovascular and interventional radiology · 2025Article
- Incidence, Risk Factors, and Stroke Prevention During Transcatheter Aortic Valve Implantation.Reviews in cardiovascular medicine · 2025Review
- Nomogram to predict 1-year cognitive decline after stent placement for unruptured intracranial aneurysms.iScience · 2025Article
- Neural Correlates and Adaptive Mechanisms in Vascular Cognitive Impairment: Exploration of a Structure-Function Coupling Network.CNS neuroscience & therapeutics · 2025Article
- Association of direct oral anticoagulants and warfarin with incidence of dementia in atrial fibrillation patients: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2024Review
- Association of Atrial Fibrillation and Cognitive Dysfunction: A Comprehensive Narrative Review of Current Understanding and Recent Updates.Journal of clinical medicine · 2024Review
- Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications.Biomolecules · 2024Review
- Bibliometric Insights Into the Evolution of Atrial Fibrillation and Dementia Research 2002-2022.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Article
- Post-stroke Everything.Current neurology and neuroscience reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSilent brain infarction (SBI) may be associated with cognitive decline in the general population. We systematically reviewed prior literature on: (1) SBI and cognition cross-sectionally; (2) baseline SBI and future cognitive decline and risk for cognitive disorders including dementia, and (3) incident SBI and the emergence of cognitive decline or cognitive disorders.
methodsThe MEDLINE and EMBASE databases were searched for relevant studies. Data were independently extracted by two reviewers. Quality was assessed using the Newcastle Ottawa Scale. Data were pooled using a random effects model when more than two comparable estimates were found.
resultsThirty relevant studies were identified: 17 had a cross-sectional design, 10 evaluated the association of baseline SBI with future cognitive decline, and 5 evaluated the association of incident SBI with cognitive decline. Most cross-sectional studies reported lower cognitive performance in persons with SBI. The pooled risk for incident dementia in persons with SBI was 1.48 (95% CI 1.12-1.97), but there was significant heterogeneity (p = 0.009); removing one outlier eliminated the heterogeneity (p = 0.53), giving a lower but still significant estimate (hazard ratio 1.27, 95% CI 1.06-1.51). The pooled risk for incident MCI was not increased in persons with SBI (hazard ratio 0.83, 95% CI 0.40 to 1.72), but there was significant heterogeneity (p < 0.001). The appearance of new SBI was associated with steeper rate of cognitive decline and the appearance of dementia.
conclusionsSBI are associated with worse cognition and increased risk for dementia. More standardization of cognitive assessment methods would facilitate future cross-study comparisons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.