Observational studyJournal of neurology2020
Risk of Parkinson's disease after colectomy: longitudinal follow-up study using a national sample cohort.
Observational study in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis.Molecular neurobiology · 2021Review
- Parkinson's disease: Are gut microbes involved?American journal of physiology. Gastrointestinal and liver physiology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeParkinson's disease (PD) is a neurodegenerative disorder characterized by deposition of intraneural inclusion bodies in the brain as well as the enteric nervous system. Emerging concepts regarding the brain-gut axis have been proposed for neurological disorders. Thus, the present study investigated the associations between colectomy and developing PD.
methodsWe conducted a retrospective cohort study using National Health Insurance Service-National Sample Cohort of Korea. This study included patients who underwent colectomy during 2003-2009, and up to 10 individuals per patient, matched in terms of age and sex, who did not undergo colectomy. The colectomy group was subdivided by the causes and surgical methods of colectomy. The risk of PD occurrence was evaluated over a follow-up period of at least 6 years using Cox regression analyses.
resultsColectomy was associated with a higher risk of developing PD (adjusted hazard ratio [HR]: 1.962; 95% confidence interval [CI] 1.002-3.840). There was no significant difference in the occurrence of PD among the subgroups classified by the causes or surgical methods of colectomy.
conclusionsColectomy was associated with the development of PD, suggesting that colon issues play an important role in the pathophysiological mechanisms of PD.
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