Evidence map›Paper›PMID 31691001›Full record

ArticleEuropean journal of pediatrics2020

Celiac disease and complement activation in response to Streptococcus pneumoniae.

Anna Röckert Tjernberg, Hanna Woksepp, Kerstin Sandholm, Marcus Johansson, Charlotte Dahle, Jonas F Ludvigsson, Jonas Bonnedahl, Per Nilsson, Kristina Nilsson Ekdahl

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. From Villi to Alveoli: Lung Involvement in Celiac Disease - A Narrative Review.Journal of community hospital internal medicine perspectives · 2026
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Anna Röckert TjernbergDepartment of Pediatrics, Kalmar County Hospital, SE-391 85, Kalmar, Sweden. anna.rockert@regionkalmar.se.ORCID http://orcid.org/0000-0001-8126-9738
Hanna WokseppResearch section, Department of Development and Public Health, Kalmar County Hospital, SE-391 85, Kalmar, Sweden.
Kerstin SandholmLinnaeus Center for Biomaterials Chemistry, Linnaeus University, SE-391 82, Kalmar, Sweden.
Marcus JohanssonDepartment of Clinical Microbiology, Kalmar County Hospital, SE-391 85, Kalmar, Sweden.
Charlotte DahleDepartment of Clinical and Experimental Medicine, Linköping University, SE-581 85, Linköping, Sweden.
Jonas F LudvigssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Jonas BonnedahlDepartment of Clinical and Experimental Medicine, Linköping University, SE-581 85, Linköping, Sweden.
Per NilssonLinnaeus Center for Biomaterials Chemistry, Linnaeus University, SE-391 82, Kalmar, Sweden.
Kristina Nilsson EkdahlLinnaeus Center for Biomaterials Chemistry, Linnaeus University, SE-391 82, Kalmar, Sweden.
Linköping University · SEÖrebro University · SELandstinget i Kalmar län · SELinnaeus University · SEOslo University Hospital · NOUppsala University · SE

Funding

Forskningsrådet i Sydöstra Sverige 658741
6 · The paper itself

Abstract

Individuals with celiac disease (CD) are at increased risk of invasive pneumococcal disease (IPD). The aim of this study was to explore whether the complement response to Streptococcus pneumoniae differed according to CD status, and could serve as an explanation for the excess risk of IPD in CD. Twenty-two children with CD and 18 controls, born 1999-2008, were included at Kalmar County Hospital, Sweden. The degree of complement activation was evaluated by comparing levels of activation products C3a and sC5b-9 in plasma incubated for 30 min with Streptococcus pneumoniae and in non-incubated plasma. Complement analyses were performed with enzyme-linked immunosorbent assay (ELISA). Pneumococcal stimulation caused a statistically significant increase in C3a as well as sC5b-9 in both children with CD and controls but there was no difference in response between the groups. After incubation, C3a increased on average 4.6 times and sC5b-9 22 times in both the CD and the control group (p = 0.497 and p = 0.724 respectively).Conclusion: Complement response to Streptococcus pneumoniae seems to be similar in children with and without CD and is thus unlikely to contribute to the increased susceptibility to invasive pneumococcal disease in CD.What is Known:• An excess risk of pneumococcal infections has been demonstrated in individuals with celiac disease.• Infectious complications can depend on hyposplenism but alternative mechanisms are sparsely examined.What is New:• Complement activation in response to Streptococcus pneumoniae was examined in children with and without celiac disease but no differences could be demonstrated.

Indexed as

Complement ActivationAdolescentBiomarkersCase-Control StudiesCeliac DiseaseChildComplement C3aComplement Membrane Attack ComplexDisease SusceptibilityEnzyme-Linked Immunosorbent AssayFemaleHumansMalePneumococcal InfectionsRisk FactorsBiomarkersComplement C3aComplement Membrane Attack ComplexSC5b-9 protein complexCoeliacInfectionInnate immunityMBLPneumococcal

Identifiers

PMID31691001
PMCPMC6942560
OpenAlexW2972622391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.