ArticleEuropean biophysics journal : EBJ2019
Thermodynamics of DNA: heat capacity changes on duplex unfolding.
Article in European biophysics journal : EBJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Thermophysical Properties of a tRNA Isodecoder.The journal of physical chemistry. B · 2026Article
- Mechanism of DNA Chemical Denaturation.ACS omega · 2025Article
- DNA calorimetric force spectroscopy at single base pair resolution.Nature communications · 2025Article
- Effect of pH on Diclofenac-Lysozyme Interaction: Structural and Functional Aspect.Frontiers in molecular biosciences · 2022Article
- Anion-specific structure and stability of guanidinium-bound DNA origami.Computational and structural biotechnology journal · 2022Article
- Thermodynamic basis of the α-helix and DNA duplex.European biophysics journal : EBJ · 2021Article
- Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange.Nucleic acids research · 2020Article
- Forces maintaining the DNA double helix.European biophysics journal : EBJ · 2020Article
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3 authors.
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Abstract
The heat capacity change, ΔCp, accompanying the folding/unfolding of macromolecules reflects their changing state of hydration. Thermal denaturation of the DNA duplex is characterized by an increase in ΔCp but of much lower magnitude than observed for proteins. To understand this difference, the changes in solvent accessible surface area (ΔASA) have been determined for unfolding the B-form DNA duplex into disordered single strands. These showed that the polar component represents ~ 55% of the total increase in ASA, in contrast to globular proteins of similar molecular weight for which the polar component is only about 1/3rd of the total. As the exposure of polar surface results in a decrease of ΔCp, this explains the much reduced heat capacity increase observed for DNA and emphasizes the enhanced role of polar interactions in maintaining duplex structure. Appreciation of a non-zero ΔCp for DNA has important consequences for the calculation of duplex melting temperatures (T
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