Evidence map›Paper›PMID 31690829›Full record

ReviewNature reviews. Gastroenterology & hepatology2020

Management of functional constipation in children and adults.

Mana H Vriesman, Ilan J N Koppen, Michael Camilleri, Carlo Di Lorenzo, Marc A Benninga

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 230 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 21 pooled it
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710654 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Different Physiotherapy Programs on Symptoms and Quality of Life in Individuals With Functional Constipation

TypeinterventionalSponsorMuş Alparslan UniversityRan2021 to 2022Enrolled52ConditionsFunctional ConstipationArmsconnective tissue manipulation, Interferential current stimulation (100 Hz frequency), Interferential current stimulation (0-100 Hz frequency), behavioural therapy, exercise program
NCT05035784 nacompletednot on this map

Retrograde Colonic Enema With Fecal Microbiota Transplantation vs Retrograde Colonic Enema Only in the Treatment of Childhood Constipation

TypeinterventionalSponsorShengjing HospitalRan2020 to 2022Enrolled110ConditionsFecal Microbiota Transplantation, Constipation - FunctionalArmsFecal supernatant, Placebo
NCT06785844 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Intra-rectal Botulinum Toxin Injection for Intractable Non-retentive Fecal Incontinence in Children - an Open Label Pilot Study

TypeinterventionalSponsorShaare Zedek Medical CenterRan2025 to 2030Enrolled14ConditionsFecal IncontinenceArmsBotulinum Toxin A (Botox )
3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 21 syntheses or guidelines pooled it, 426 citations in OpenAlex.

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170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Mana H VriesmanDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. m.h.vriesman@amc.nl.ORCID http://orcid.org/0000-0002-4759-8447
Ilan J N KoppenDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Michael CamilleriC.E.N.T.E.R. Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Carlo Di LorenzoDivision of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, OH, USA.
Marc A BenningaDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Emma Kinderziekenhuis · NLMayo Clinic in Arizona · USNationwide Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional constipation is common in children and adults worldwide. Functional constipation shows similarities in children and adults, but important differences also exist regarding epidemiology, symptomatology, pathophysiology, diagnostic workup and therapeutic management. In children, the approach focuses on the behavioural nature of the disorder and the initial therapeutic steps involve toilet training and laxatives. In adults, management focuses on excluding an underlying cause and differentiating between different subtypes of functional constipation - normal transit, slow transit or an evacuation disorder - which has important therapeutic consequences. Treatment of adult functional constipation involves lifestyle interventions, pelvic floor interventions (in the presence of a rectal evacuation disorder) and pharmacological therapy. When conventional treatments fail, children and adults are considered to have intractable functional constipation, a troublesome and distressing condition. Intractable constipation is managed with a stepwise approach and in rare cases requires surgical interventions such as antegrade continence enemas in children or colectomy procedures for adults. New drugs, including prokinetic and prosecretory agents, and surgical strategies, such as sacral nerve stimulation, have the potential to improve the management of children and adults with intractable functional constipation.

Indexed as

AdultBile Acids and SaltsBiofeedback, PsychologyChildChloride Channel AgonistsCholinesterase InhibitorsConstipationDietary FiberDiet TherapyDisease ManagementElectric Stimulation TherapyEnemaGastrointestinal AgentsGastrointestinal MicrobiomeGastrointestinal TransitGuanylyl Cyclase C AgonistsBile Acids and SaltsChloride Channel AgonistsCholinesterase InhibitorsDietary FiberGastrointestinal AgentsGuanylyl Cyclase C AgonistsLaxativesPrebioticsSerotonin 5-HT4 Receptor Agonists

Identifiers

PMID31690829
OpenAlexW2987715292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.