Evidence map›Paper›PMID 31690822›Full record

ArticleLeukemia2020

ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.

Arina Riabinska, Daria Lehrmann, Ron Daniel Jachimowicz, Gero Knittel, Christian Fritz, Anna Schmitt, Aenne Geyer, Carola Heneweer, Maike Wittersheim, Lukas P Frenzel and 23 more

Abstract read
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In one paragraph

Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Oxidative Stress Early After Hematopoietic Stem Cell Transplant.Transplantation and cellular therapy · 2025
    Article
  2. Article
  3. Article
  4. Mouse models of diffuse large B cell lymphoma.Frontiers in immunology · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 11 institutions in 1 country.

Arina RiabinskaClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany. arina.riabinska@uk-koeln.de.
Daria LehrmannClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Ron Daniel JachimowiczClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Gero KnittelClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Christian FritzClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Anna SchmittClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Aenne GeyerClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Carola HeneweerDepartment of Radiology, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Maike WittersheimInstitute of Pathology, University Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Lukas P FrenzelClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Alessandro TorgovnickClinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Janica Lea WiedersteinCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50937, Germany.
Claudia Maria WunderlichMax Planck Institute for Metabolism Research, Cologne, 50937, Germany.
Monika OrtmannInstitute of Pathology, University Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Arlette PaillardIntitute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, 50937, Germany.
Wilhelm WößmannDepartment of Pediatric Hematology and Oncology, Justus-Liebig-University, Giessen, 35390, Germany.
Arndt BorkhardtDepartment of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Heinrich Heine University, Medical Faculty, Düsseldorf, 40225, Germany.
Stefan BurdachChildren's Cancer Research Center and Department of Pediatrics, Rechts der Isar Hospital, Technical University of Munich and Comprehensive Cancer Center Munich, Munich, 80333, Germany.
Martin-Leo HansmannInstitute of Pathology, University of Frankfurt, Medical School, Frankfurt, 60590, Germany.
Andreas RosenwaldInstitute of Pathology, University of Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, 97080, Germany.
Sven PernerInstitute of Pathology, University Hospital Schleswig-Holstein, Lübeck, 23538, Germany.
Gita MallInstitute of Forensic Medicine, University Hospital Jena, Jena, 07743, Germany.
Wolfram KlapperPathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, 24105, Germany.ORCID http://orcid.org/0000-0001-7208-4117
Andrea MerseburgExperimental Neurophysiology, German Center for Neurodegenerative Diseases, Bonn, 53175, Germany.
Marcus KrügerCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50937, Germany.
Holger GrüllDepartment of Radiology, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Thorsten PersigehlDepartment of Radiology, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Frank Thomas WunderlichMax Planck Institute for Metabolism Research, Cologne, 50937, Germany.ORCID http://orcid.org/0000-0002-9209-3501
Martin PeiferCenter for Molecular Medicine Cologne, University of Cologne, Cologne, 50937, Germany.
Olaf UtermöhlenIntitute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, 50937, Germany.
Reinhard BüttnerInstitute of Pathology, University Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Filippo Beleggia *Clinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany.
Hans Christian Reinhardt *Clinic I of Internal Medicine, University Hospital Cologne, Medical Faculty, University of Cologne, Cologne, 50937, Germany. christian.reinhardt@uk-koeln.de.
University of Cologne · DEMax Planck Institute for Metabolism Research · DEUniversity Hospital Schleswig-Holstein · DEDüsseldorf University Hospital · DEGerman Center for Neurodegenerative Diseases · DEGoethe University Frankfurt · DEJena University Hospital · DEJustus-Liebig-Universität Gießen · DETH Köln - University of Applied Sciences · DETUM Klinikum · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer predisposition. Whether ATM deficiency impacts on tumor initiation or also on the maintenance of the malignant state is unclear. Here, we show that Atm reactivation in initially Atm-deficient B- and T cell lymphomas induces tumor regression. We further find a reduced T cell abundance in B cell lymphomas from Atm-defective mice and A-T patients. Using T cell-specific Atm-knockout models, as well as allogeneic transplantation experiments, we pinpoint impaired immune surveillance as a contributor to cancer predisposition and development. Moreover, we demonstrate that Atm-deficient T cells display impaired proliferation capacity upon stimulation, due to replication stress. Altogether, our data indicate that T cell-specific restoration of ATM activity or allogeneic hematopoietic stem cell transplantation may prevent lymphomagenesis in A-T patients.

Indexed as

AllelesAnimalsAtaxia Telangiectasia Mutated ProteinsCell ProliferationEtoposideHematopoietic Stem Cell TransplantationLymphomaMiceMice, KnockoutT-LymphocytesTransplantation, HomologousTreatment OutcomeAtaxia Telangiectasia Mutated ProteinsAtm protein, mouseEtoposide

Identifiers

PMID31690822
OpenAlexW2985370010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.