Evidence map›Paper›PMID 31690812›Full record

ArticleScientific reports2019

Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.

Yasuyuki Shiraishi, Atsushi Kimura, Osamu Matsuo, Yoichi Sakata, Katsushi Takeshita, Tsukasa Ohmori

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Repurposing of Chemokine Antagonists for Combined Phase-Resolved Spinal Cord Injury Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yasuyuki ShiraishiDepartment of Orthopaedics, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
Atsushi KimuraDepartment of Orthopaedics, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan. akimura@jichi.ac.jp.
Osamu MatsuoKindai University Faculty of Medicine, Osakasayama, 589-8511, Japan.
Yoichi SakataDepartment of Biochemistry, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
Katsushi TakeshitaDepartment of Orthopaedics, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.
Tsukasa OhmoriDepartment of Biochemistry, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.ORCID http://orcid.org/0000-0001-5082-6394
Jichi Medical University · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is caused by an initial mechanical insult followed by a series of deleterious events that promote the progressive damage of affected tissues. Fibrinolysis, the process by which plasmin degrades cross-linked fibrin clots, has numerous functions in the central nervous system. However, the roles of the fibrinolytic system in SCI pathophysiology remain unknown. We investigated the roles of fibrinolysis in SCI, and explored therapeutic applications targeting fibrinolysis. Plasminogen-deficient (Plg

Indexed as

Acute DiseaseAnimalsChemokinesCytokinesFibrinolysisLocomotionMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Inbred C57BLMice, KnockoutPlasminogenRecovery of FunctionSpinal CordSpinal Cord InjuriesTranexamic AcidChemokinesCytokinesMatrix Metalloproteinase 2Matrix Metalloproteinase 9PlasminogenTranexamic Acid

Identifiers

PMID31690812
PMCPMC6831600
OpenAlexW2983234807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.