Evidence map›Paper›PMID 31690811›Full record

ArticleScientific reports2019

Steady-state activation of the high-affinity isoform of the α4β2δ GABA

Spencer R Pierce, Thomas C Senneff, Allison L Germann, Gustav Akk

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Reduced Activation of the Synaptic-Type GABAMolecular pharmacology · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Spencer R PierceDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Thomas C SenneffDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Allison L GermannDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Gustav AkkDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. akk@morpheus.wustl.edu.
Washington University in St. Louis · US

Funding

SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580
6 · The paper itself

Abstract

Activation of GABA

Indexed as

AnimalsGABA-A Receptor AgonistsHumansKineticsPregnanolonePropofolProtein IsoformsReceptors, GABA-AXenopus laevisGABA-A Receptor AgonistsGABRA4 protein, humanGABRB2 protein, humanGABRG1 protein, humanPregnanolonePropofolProtein IsoformsReceptors, GABA-A

Identifiers

PMID31690811
PMCPMC6831628
OpenAlexW2987427432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.