Evidence map›Paper›PMID 31690793›Full record

ArticleScientific reports2019

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study.

Khalid Zaman, Fazal Rahim, Muhammad Taha, Abdul Wadood, Syed Adnan Ali Shah, Qamar Uddin Ahmed, Zainul Amiruddin Zakaria

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Synthesis, characterization,RSC advances · 2026
    Article
  2. Article
  3. Pyrrolo[2,1-RSC advances · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Khalid ZamanDepartment of Chemistry, Hazara University, Mansehra, 21300, Khyber Pakhtunkhwa, Pakistan.
Fazal RahimDepartment of Chemistry, Hazara University, Mansehra, 21300, Khyber Pakhtunkhwa, Pakistan.
Muhammad TahaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia. mtaha@iau.edu.sa.ORCID http://orcid.org/0000-0003-3047-9289
Abdul WadoodDepartment of Biochemistry, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan.
Syed Adnan Ali ShahFaculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor, D.E., Malaysia.
Qamar Uddin AhmedDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Pahang DM, Kuantan, 25200, Malaysia.
Zainul Amiruddin ZakariaDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. zaz@upm.edu.my.
Hazara University · PKAbdul Wali Khan University Mardan · PKImam Abdulrahman Bin Faisal University · SAInternational Islamic University Malaysia · MYUniversiti Putra Malaysia · MYUniversiti Teknologi MARA · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threats. In connection with this, we have synthesized twenty derivatives of isoquinoline bearing oxadiazole (1-20), characterized through different spectroscopic techniques such as HREI-MS,

Indexed as

Molecular Docking SimulationBinding SitesEnzyme InhibitorsEscherichia coliEscherichia coli ProteinsHumansInhibitory Concentration 50IsoquinolinesMagnetic Resonance SpectroscopyOxadiazolesProtein Structure, TertiaryStructure-Activity RelationshipThymidine PhosphorylaseXanthines7-deazaxanthineEnzyme InhibitorsEscherichia coli ProteinsisoquinolineIsoquinolinesOxadiazolesThymidine PhosphorylaseXanthines

Identifiers

PMID31690793
PMCPMC6831664
OpenAlexW2985212085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.