ArticleScientific reports2019
Fengycin induces ion channels in lipid bilayers mimicking target fungal cell membranes.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Role of C17 fengycin B fromApplied and environmental microbiology · 2026Article
- Biocontrol of mushroom crop mycoparasites by novel Bacillus velezensis strains.Applied microbiology and biotechnology · 2026Article
- Biocontrol of mushroom crop mycoparasites by novelbioRxiv : the preprint server for biology · 2026Article
- Broad-Spectrum Antibacterial Action of Lipopeptides Derived from Bacillus smithii by Targeting Quorum Sensing.Probiotics and antimicrobial proteins · 2026Article
- Lipopeptide Engineering: From Natural Origins to Rational Design Against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2026Review
- Genomic and microecological insights into the biocontrol mechanisms ofFrontiers in microbiology · 2026Article
- State of the Art of Cyclic Lipopeptide-Membrane Interactions: Pore Formation and Bilayer Permeability.Pharmaceutics · 2025Review
- Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.Antibiotics (Basel, Switzerland) · 2023Review
- The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: AnFrontiers in chemistry · 2023Article
- Lipid Microenvironment Modulates the Pore-Forming Ability of Polymyxin B.Antibiotics (Basel, Switzerland) · 2022Article
- Candidacidal and Antibiofilm Activity of PS1-3 Peptide against Drug-ResistantPharmaceutics · 2022Article
- Target Mechanism of Iturinic Lipopeptide on Differential Expression Patterns of Defense-Related Genes againstPlants (Basel, Switzerland) · 2022Article
- Rhamnolipids and fengycins, very promising amphiphilic antifungal compounds from bacteria secretomes, act onFrontiers in microbiology · 2022Article
- Discovering the Next-Generation Plant Protection Products: A Proof-of-Concept via the Isolation and Bioactivity Assessment of the Olive Tree EndophyteMetabolites · 2021Article
- Honey as an Ecological Reservoir of Antibacterial Compounds Produced by Antagonistic Microbial Interactions in Plant Nectars, Honey and Honey Bee.Antibiotics (Basel, Switzerland) · 2021Review
- Antibacterial Activity ofApplied and environmental microbiology · 2020Article
- 1,3-Thiazine, 1,2,3,4-Dithiadiazole, and Thiohydrazide Derivatives Affect Lipid Bilayer Properties and Ion-Permeable Pores Induced by Antifungals.Frontiers in cell and developmental biology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The one-sided addition of fengycin (FE) to planar lipid bilayers mimicking target fungal cell membranes up to 0.1 to 0.5 μM in the membrane bathing solution leads to the formation of well-defined and well-reproducible single-ion channels of various conductances in the picosiemens range. FE channels were characterized by asymmetric conductance-voltage characteristic. Membranes treated with FE showed nonideal cationic selectivity in potassium chloride bathing solutions. The membrane conductance induced by FE increased with the second power of the lipopeptide aqueous concentration, suggesting that at least FE dimers are involved in the formation of conductive subunits. The pore formation ability of FE was not distinctly affected by the molecular shape of membrane lipids but strongly depended on the presence of negatively charged species in the bilayer. FE channels were characterized by weakly pronounced voltage gating. Small molecules known to modify the transmembrane distribution of electrical potential and the lateral pressure profile were used to modulate the channel-forming activity of FE. The observed effects of membrane modifiers were attributed to changes in lipid packing and lipopeptide oligomerization in the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.