ArticleScientific reports2019
Metabolite Profiling and Quantitation of Cucurbitacins in Cucurbitaceae Plants by Liquid Chromatography coupled to Tandem Mass Spectrometry.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Opening the black box: study of the multi-target anticancer mechanisms ofRSC advances · 2026Article
- Cucurbitacins in Plant-Insect Interactions: Biosynthesis, Regulation, Ecological Functions, and Prospects for Crop Protection.Plants (Basel, Switzerland) · 2026Review
- Plant-Derived Bioactive Compounds and Their Therapeutic Potential in Cancer.International journal of molecular sciences · 2026Review
- GenusChinese herbal medicines · 2026Review
- Profiling and cheminformatics bioprospection of curcurbitacin I and momordin Ic fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
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- Cucurbitane Glycosides and Their Potential Anti-Inflammatory Activities fromMolecules (Basel, Switzerland) · 2025Article
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- UHPLC-HRMS/MS-Based Metabolic Profiling and Quantification of Phytochemicals in Different Parts ofFood science & nutrition · 2025Article
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- Anticancer activity, phytochemical investigation and molecular docking insights of Citrullus colocynthis (L.) fruits.Scientific reports · 2023Article
- Cucurbitacins B, E and I Concentrations and Relationship with Drought Tolerance in Bottle Gourd [Plants (Basel, Switzerland) · 2023Article
- Aphid adaptation to cucurbits: sugars, cucurbitacin and phloem structure in resistant and susceptible melons.BMC plant biology · 2023Article
- Effect of Juglone and Other Allelochemicals in Walnut Leaves on Yield, Quality and Metabolites of Snack Cucumber (Foods (Basel, Switzerland) · 2023Article
- Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms.Journal of translational medicine · 2022Review
- In Vitro Sprouted Plantlets ofPlants (Basel, Switzerland) · 2022Article
- Impact of Geraniol and Geraniol Nanoemulsions onPlants (Basel, Switzerland) · 2022Article
- Anticancer properties of medicinal plants and their bioactive compounds against breast cancer: a review on recent investigations.Environmental science and pollution research international · 2022Review
- The Nutritional Properties, Chemical Compositions, and Functional Characteristics of the Aerial Parts ofFrontiers in nutrition · 2022Article
- Comparative metabolomics reveals the cytotoxic and anti-inflammatory discriminatory chemical markers of raw and roasted colocynth fruit (RSC advances · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cucurbitaceae is an important plant family because many of its species are consumed as food, and used in herbal medicines, cosmetics, etc. It comprises annual vines and is rich in various bioactive principles which include the cucurbitacins. These steroidal natural products, derived from the triterpene cucurbitane, are mainly the bitter principles of the family Cucurbitaceae. Their biological activities include anti-inflammatory, hepatoprotective, and anti-cancer activities. A total of 10 species belonging to 6 genera of the Cucurbitaceae family along with Cissampelos pareira (Menispermaceae) were included in this study. A comprehensive profiling of certain natural products was developed using HPLC-QTOF-MS/MS analysis and a distribution profile of several major natural products in this family was obtained. A total of 51 natural products were detected in both positive and negative ionization modes, based on accurate masses and fragmentation patterns. Along with this, quantitation of four bioactive cucurbitacins, found in various important plants of the Cucurbitaceae family, was carried out using multiple reaction monitoring (MRM) approach on an ion trap mass spectrometer. Cucurbitacin Q was found to be the most abundant in C. pareira, while Citrullus colocynthis contained all four cucurbitacins in abundant quantities. The developed quantitation method is simple, rapid, and reproducible.
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