Evidence map›Paper›PMID 31690685›Full record

ArticleNeurology2019

Migraine progression in subgroups of migraine based on comorbidities: Results of the CaMEO Study.

Richard B Lipton, Kristina M Fanning, Dawn C Buse, Vincent T Martin, Lee B Hohaia, Aubrey Manack Adams, Michael L Reed, Peter J Goadsby

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01648530 (Chronic Migraine Epidemiology and Outcomes Study), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01648530 completednot on this map

Chronic Migraine Epidemiology and Outcomes Study

TypeobservationalSponsorAllerganRan2012 to 2013Enrolled16,789ConditionsMigraine DisordersArmsNo Treatment
3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Richard B LiptonFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco. Richard.Lipton@einstein.yu.edu.
Kristina M FanningFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
Dawn C BuseFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
Vincent T MartinFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
Lee B HohaiaFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
Aubrey Manack AdamsFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
Michael L ReedFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.
Peter J GoadsbyFrom the Albert Einstein College of Medicine (R.B.L., D.C.B.), Bronx, NY; Vedanta Research (K.M.F., M.L.R.), Chapel Hill, NC; University of Cincinnati Headache and Facial Pain Center (V.T.M.), University of Cincinnati College of Medicine, OH; CHC Group, LLC (L.B.H.), North Wales, PA; Allergan plc (A.M.A.), Irvine, CA; NIHR-Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College, London, UK; and Department of Neurology (P.J.G.), University of California, San Francisco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo test the hypothesis that statistically defined subgroups of migraine (based on constellations of comorbidities and concomitant conditions; henceforth comorbidities), previously identified using Chronic Migraine Epidemiology and Outcomes (CaMEO) Study data, differ in prognosis, as measured by rates of progression from episodic migraine (EM) to chronic migraine (CM).

methodsThe onset of CM was assessed up to 4 times over 12 months in individuals with EM and ≥1 comorbidity at baseline, based on constellations of comorbidities (comorbidity classes). The "fewest comorbidities" class served as reference. Individuals completing ≥1 follow-up survey from the web-based CaMEO Study were included. Covariates included sociodemographic variables and headache characteristics. Sex, income, cutaneous allodynia, and medication overuse were modeled as binary variables; age, body mass index, headache-related disability (Migraine Disability Assessment [MIDAS]), and Migraine Symptom Severity Scale as continuous variables. CM onset was assessed using discrete time analysis.

resultsIn the final sociodemographic model, all comorbidity classes had significantly elevated hazard ratios (HRs) for risk of progression to CM from EM, relative to fewest comorbidities. HRs for CM onset ranged from 5.34 (95% confidence interval [CI] 3.89-7.33;

conclusionsSubgroups of migraine identified by comorbidity classes at cross-section predicted progression from EM (with ≥1 comorbidity at baseline) to CM. The relationship of comorbidity group to CM onset remained after adjusting for indicators of migraine severity, such as MIDAS. CLINICALTRIALSGOV IDENTIFIER: NCT01648530.

Indexed as

Disease ProgressionSelf ReportAdultCardiovascular DiseasesChronic DiseaseComorbidityCross-Sectional StudiesFemaleHumansMaleMental DisordersMiddle AgedMigraine DisordersRespiration DisordersTreatment Outcome

Identifiers

PMID31690685
PMCPMC6937494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.