Evidence map›Paper›PMID 31690675›Full record

ArticlemBio2019

A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus.

Hyeok-Il Kwon, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Semi Kim, Young-Jae Si, Min-Suk Song, Philippe Noriel Q Pascua, Elena A Govorkova, Robert G Webster and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Hyeok-Il KwonCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Young-Il KimCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Su-Jin ParkCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Eun-Ha KimCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Semi KimCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Young-Jae SiCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Min-Suk SongCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.ORCID 0000-0001-6073-0783
Philippe Noriel Q PascuaCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
Elena A GovorkovaDivision of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Robert G WebsterDivision of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Richard J WebbyDivision of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA richard.webby@stjude.org choiki55@chungbuk.ac.kr.
Young Ki ChoiCollege of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea richard.webby@stjude.org choiki55@chungbuk.ac.kr.
Chungbuk National University · KRSt. Jude Children's Research Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism allows for systemic infection of chickens, ducks, and mice, and A/Mdk/6L/07 can replicate

Indexed as

AnimalsChickensDucksFemaleHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza in BirdsMiceMice, Inbred BALB CNeuraminidaseViral ProteinsVirulenceHemagglutinin Glycoproteins, Influenza VirusNeuraminidaseViral ProteinsGRG motifH7influenzaN6 neuraminidasepathogenicitythrombin-like proteasetrypsin-independent growthvirulence

Identifiers

PMID31690675
PMCPMC6831776
OpenAlexW2985288363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.