Evidence map›Paper›PMID 31690632›Full record

ArticleThe Journal of biological chemistry2019

Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α-FGF21 axis in mice.

Ahmed Aljohani, Mohammad Imran Khan, Abram Bonneville, Changan Guo, Justin Jeffery, Lucas O'Neill, Deeba Nadeem Syed, Sarah A Lewis, Maggie Burhans, Hasan Mukhtar and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Role of ChREBP-PPARα-FGF21 Axis in Metabolic Dysfunction of MASLD.International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease.International journal of molecular sciences · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Ahmed AljohaniEndocrinology and Reproductive Physiology Graduate Training Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706.
Mohammad Imran KhanSchool of Medicine and Public Health, Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706.ORCID 0000-0002-8761-0017
Abram BonnevilleDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Changan GuoDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Justin JefferyCarbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53706.
Lucas O'NeillDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Deeba Nadeem SyedSchool of Medicine and Public Health, Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706.ORCID 0000-0001-6948-5817
Sarah A LewisDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Maggie BurhansDepartment of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706.
Hasan MukhtarSchool of Medicine and Public Health, Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706.
James M NtambiDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 james.ntambi@wisc.edu.ORCID 0000-0001-9784-9550
University of Wisconsin–Madison · US

Funding

Role of Stearoyl-CoA Desaturase in MetabolismR01DK062388 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI NTAMBI, JAMES M. · 2002 to 2010
$2.6M
Role of Liver Stearoyl-CoA Desaturase-1 in the Regulation of MetabolismR01DK118093 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI NTAMBI, JAMES M. · 2018 to 2020
$1.1M
NIDDK NIH HHS R01 DK062388NIDDK NIH HHS R01 DK118093
6 · The paper itself

Abstract

Increased carbohydrate consumption increases hepatic

Indexed as

AdiponectinAdipose TissueAdiposityAnimalsCarbohydrate MetabolismDietFatty Acids, MonounsaturatedFatty LiverFibroblast Growth FactorsGlucoseInsulinLipid MetabolismLipogenesisLiverMaleMiceAdiponectinFatty Acids, Monounsaturatedfibroblast growth factor 21Fibroblast Growth FactorsGlucoseInsulinOleic AcidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseScd1 protein, mouseStearoyl-CoA Desaturaseadiponectincarbohydrate metabolismfibroblast growth factor (FGF)glucose metabolismglucose transportglucose transportersheptokine-FGF21insulin sensitivitylipid metabolismlipid signalingliverliver–adipocyte cross-talkliver metabolismmonounsaturated fatty acidsobesitystearoyl-CoA desaturase-1

Identifiers

PMID31690632
PMCPMC6926457
OpenAlexW2985980598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.