Evidence map›Paper›PMID 31690625›Full record

ArticleThe Journal of biological chemistry2019

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation.

Michelle S Miller, Jacqueline Douglass, Michael S Hwang, Andrew D Skora, Michael Murphy, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B Gabelli

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Design of high specificity binders for peptide-MHC-I complexes.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Neoantigens: promising targets for cancer therapy.Signal transduction and targeted therapy · 2023
    Review
  9. Review
  10. TCR-mimic bispecific antibodies to target the HIV-1 reservoir.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Liquid Biopsy, ctDNA Diagnosis through NGS.Life (Basel, Switzerland) · 2021
    Review
  13. Review
  14. Targeting loss of heterozygosity for cancer-specific immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Targeting a neoantigen derived from a commonScience (New York, N.Y.) · 2021
    Article
  16. Bispecific antibodies targeting mutantScience immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michelle S MillerDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.ORCID 0000-0003-1972-4503
Jacqueline DouglassLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Michael S HwangLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Andrew D SkoraLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Michael MurphyGE Healthcare Life Sciences, Marlborough, Massachusetts 01752.
Nickolas PapadopoulosLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Kenneth W KinzlerLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Bert VogelsteinLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Shibin ZhouLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Sandra B GabelliDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 gabelli@jhmi.edu.ORCID 0000-0003-1205-5204
Johns Hopkins University · USHoward Hughes Medical Institute · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, ALISON P · 1993 to 2022
$54.6M
Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NIDDK NIH HHS P30 DK089502NIGMS NIH HHS P41 GM111244
6 · The paper itself

Abstract

Mutations in

Indexed as

Protein Engineeringbeta CateninCell LineHistocompatibility Antigens Class IHumansImmunoglobulin FragmentsModels, MolecularMutationbeta CateninHistocompatibility Antigens Class IImmunoglobulin Fragmentsantibody engineeringbeta-catenincancercatenin beta 1 (CTNNB1)human leukocyte antigen (HLA)immunotherapymajor histocompatibility complex (MHC) class IMANAbodyneoantigenphage display

Identifiers

PMID31690625
PMCPMC6916501
OpenAlexW2984164384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.