Evidence map›Paper›PMID 31690624›Full record

ArticleThe Journal of biological chemistry2019

Tango1 coordinates the formation of endoplasmic reticulum/Golgi docking sites to mediate secretory granule formation.

Hayley M Reynolds, Liping Zhang, Duy T Tran, Kelly G Ten Hagen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 64 citations in OpenAlex.

  1. Evaluating the Role ofDiagnostics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. The life cycle of type IV collagen.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  5. Article
  6. Mucins and Their Roles in Asthma.Immunological reviews · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Emerging cell and molecular targets for treating mucus hypersecretion in asthma.Allergology international : official journal of the Japanese Society of Allergology · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Sorting and Export of Proteins at the Endoplasmic Reticulum.Cold Spring Harbor perspectives in biology · 2023
    Review
  16. Article
  17. Article
  18. Regulated Restructuring of Mucins During Secretory Granule Maturation In Vivo.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Review
  20. In vivo models of mucin biosynthesis and function.Advanced drug delivery reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hayley M ReynoldsDevelopmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370.
Liping ZhangDevelopmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370.
Duy T TranNIDCR Imaging Core, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370.
Kelly G Ten HagenDevelopmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370 Kelly.Tenhagen@nih.gov.ORCID 0000-0002-2057-8120
National Institutes of Health · US

Funding

Imaging CoreZICDE000750 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DOYLE, ANDREW · 2019 to 2025
$6.9M
Role of O-glycosylation in Animal DevelopmentZ01DE000713 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TEN HAGEN, KELLY G · 2006 to 2008
$2.0M
Intramural NIH HHS Z01 DE000713Intramural NIH HHS ZIC DE000750
6 · The paper itself

Abstract

Regulated secretion is a conserved process occurring across diverse cells and tissues. Current models suggest that the conserved cargo receptor Tango1 mediates the packaging of collagen into large coat protein complex II (COPII) vesicles that move from the endoplasmic reticulum (ER) to the Golgi apparatus. However, how Tango1 regulates the formation of COPII carriers and influences the secretion of other cargo remains unknown. Here, through high-resolution imaging of Tango1, COPII, Golgi, and secretory cargo (mucins) in

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsAnimals, Genetically ModifiedAryl Hydrocarbon Receptor Nuclear TranslocatorBinding SitesCOP-Coated VesiclesDrosophila melanogasterDrosophila ProteinsEndoplasmic ReticulumGlycosylationGolgi ApparatusImage Processing, Computer-AssistedProtein TransportRNA InterferenceSalivary GlandsSecretory VesiclesAryl Hydrocarbon Receptor Nuclear TranslocatorDrosophila Proteinstgo protein, DrosophilaCOPIIDrosophilaendoplasmic reticulum (ER)glycoprotein secretionGolgiMIA SH3 domain ER export Factor 3 (MIA3); O-glycosylationmucinsalivary glandsecretionsecretory granulesTango1

Identifiers

PMID31690624
PMCPMC6926460
OpenAlexW2986725246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.