ArticlemSystems2019
Trends of Microdiversity Reveal Depth-Dependent Evolutionary Strategies of Viruses in the Mediterranean.
Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Article
- Viral modulation of sulfur-oxidizing bacteria drives organic carbon sink formation during primary succession in deglaciating ecosystems.Nature communications · 2026Article
- Viromics approaches for the study of viral diversity and ecology in microbiomes.Nature reviews. Genetics · 2026Review
- Temperate versus virulent phage lifestyle impacts microdiversity in soil environments.ISME communications · 2026Article
- Phage defence-system abundances vary across environments and increase with viral density.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Temporal dynamics, microdiversity, and ecological functions of viral communities during cyanobacterial blooms in Lake Taihu.NPJ biofilms and microbiomes · 2025Article
- A novel mobile genetic element with virus-like characteristics is widespread in the world's oceans.bioRxiv : the preprint server for biology · 2025Article
- Expanding the potential soil carbon sink: unraveling carbon sequestration accessory genes in vermicompost phages.Applied and environmental microbiology · 2025Article
- Article
- Viruses in deep-sea cold seep sediments harbor diverse survival mechanisms and remain genetically conserved within species.The ISME journal · 2023Article
- Depth-driven patterns in lytic viral diversity, auxiliary metabolic gene content, and productivity in offshore oligotrophic waters.Frontiers in microbiology · 2023Article
- Response of soil viral communities to land use changes.Nature communications · 2022Article
- Long-Read Metagenomics Improves the Recovery of Viral Diversity from Complex Natural Marine Samples.mSystems · 2022Article
- Computational Tools for the Analysis of Uncultivated Phage Genomes.Microbiology and molecular biology reviews : MMBR · 2022Review
- Unexpected myriad of co-occurring viral strains and species in one of the most abundant and microdiverse viruses on Earth.The ISME journal · 2022Article
- Viral tag and grow: a scalable approach to capture and characterize infectious virus-host pairs.ISME communications · 2022Article
- Auxiliary Metabolic Gene Functions in Pelagic and Benthic Viruses of the Baltic Sea.Frontiers in microbiology · 2022Article
- Spatial and Temporal Dynamics of Prokaryotic and Viral Community Assemblages in a Lotic System (Manatee Springs, Florida).Applied and environmental microbiology · 2021Article
- The Evolutionary Success of the Marine Bacterium SAR11 Analyzed through a Metagenomic Perspective.mSystems · 2020Article
- Quantification of Lysogeny Caused by Phage Coinfections in Microbial Communities from Biophysical Principles.mSystems · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary interactions between viruses and their prokaryotic hosts remain a little-known aspect of microbial evolution. Most studies on this topic were carried out in pure cultures that challenge one virus with one bacterial clone at a time, which is very removed from real-life situations. Few studies have addressed trends of microdiversity in marine viral communities throughout depth gradients. We analyzed metagenomes from both the cellular and viral fractions of Mediterranean seawater samples spanning the epipelagic to the bathypelagic zones at depths of 15, 45, 60, and 2,000 m during the summer stratification of the water column. We evaluated microdiversity patterns by measuring the accumulation of synonymous and nonsynonymous mutations in viral genes. Our results demonstrated clear depth-dependent trends in the frequency of polymorphic sites and nonsynonymous mutations among genes encoding metabolic, structural, and replication proteins. These differences were linked to changes in energy availability, host and viral densities, and the proportions of actively replicating viruses. We propose the hypothesis that in the energy-rich, high-host-density, euphotic depths, selection acts to favor diversity of the host recognition machinery to increase host range, while in energy-depleted aphotic waters, selection acts on viral replication fitness, enhancing diversity in auxiliary metabolic genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.