Evidence map›Paper›PMID 31690584›Full record

ArticleRNA (New York, N.Y.)2020

LncRNA-mediated regulation of

Aamira Tariq, Qinyu Hao, Qinyu Sun, Deepak K Singh, Mahdieh Jadaliha, Yang Zhang, Neha Chetlangia, Jian Ma, Sarah E Holton, Rohit Bhargava and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. SOX9: an important factor in regulating breast cancer.European journal of medical research · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Metformin and long non-coding RNAs in breast cancer.Journal of translational medicine · 2023
    Review
  11. Review
  12. eLife · 2023
    Article
  13. Article
  14. Article
  15. lncRNA GHET1 Promotes the Progression of Triple-Negative Breast CancerComputational and mathematical methods in medicine · 2022
    Article
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Aamira TariqDepartment of Biosciences, Comsats Institute of Information Technology, Islamabad 45550, Pakistan.
Qinyu HaoDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Qinyu SunDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Deepak K SinghDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Mahdieh JadalihaDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Yang ZhangComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
Neha ChetlangiaDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Jian MaComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
Sarah E HoltonDepartment of Bioengineering and Beckman Institute of Advanced Science and Technology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Rohit BhargavaDepartment of Bioengineering and Beckman Institute of Advanced Science and Technology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Supriya G PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Kannanganattu V PrasanthDepartment of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
University of Illinois Urbana-Champaign · USCarnegie Mellon University · USNational Institutes of Health · US

Funding

Discrete Frequency Infrared Spectroscopic Imaging for Breast HistopathologyR01EB009745 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT · 2010 to 2025
$5.1M
Characterization of nuclear retained RNA-mediated gene regulatory mechanismR01GM088252 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KANNANGANATTU, PRASANTH KUMAR VIJAYAN · 2011 to 2015
$1.4M
Regulation of genomic stability by ORCR01GM125196 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI PRASANTH, SUPRIYA G · 2018 to 2021
$1.3M
Role of ORCA in DNA replicationR01GM099669 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI PRASANTH, SUPRIYA G · 2012 to 2016
$1.3M
NIBIB NIH HHS R01 EB009745NIGMS NIH HHS R01 GM088252NIGMS NIH HHS R01 GM099669NIGMS NIH HHS R01 GM125196
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer (BC) subtypes with a poor prognosis and high recurrence rate. Recent studies have identified vital roles played by several lncRNAs (long noncoding RNAs) in BC pathobiology. Cell type-specific expression of lncRNAs and their potential role in regulating the expression of oncogenic and tumor suppressor genes have made them promising cancer drug targets. By performing a transcriptome screen in an isogenic TNBC/basal subtype BC progression cell line model, we recently reported ∼1800 lncRNAs that display aberrant expression during breast cancer progression. Mechanistic studies on one such nuclear-retained lncRNA,

Indexed as

BreastBreast NeoplasmsCell Line, TumorCell ProliferationCell Transformation, NeoplasticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansRNA, Long NoncodingSOX9 Transcription FactorTranscriptomeTriple Negative Breast NeoplasmsUp-RegulationRNA, Long NoncodingSOX9 protein, humanSOX9 Transcription Factorbasal-like subtypeenhancernuclear lncRNAregulationTNBC

Identifiers

PMID31690584
PMCPMC6961546
OpenAlexW2989281952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.