ArticleArchives of disease in childhood. Fetal and neonatal edition2020
EPICE cohort: two-year neurodevelopmental outcomes after very preterm birth.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Telerehabilitation-Based Family-Centered Goal-Directed Physiotherapy Approach in High Risk of Infants
Long Term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm Infants by Acetaminophen) Study (TREOCAPA-LT)
Who cites it
20 citing papers in PubMed.
- A report on parent involvement in planning a randomised controlled trial in neonatology and lactation - insights for current and future research.International breastfeeding journal · 2022Trial
- Ranibizumab in retinopathy of prematurity - one-year follow-up of ophthalmic outcomes and two-year follow-up of neurodevelopmental outcomes from the CARE-ROP study.Acta ophthalmologica · 2022Trial
- 'She's surrounded by everybody, but yet seen by nobody.' Parents' experiences and priorities for neonatal developmental follow-up care.BMJ paediatrics open · 2026Article
- Comparison of early growth and development in very preterm children in the Netherlands between the 1980s and 2000s.BMC pediatrics · 2026Article
- Congenital anomalies identified during early childhood in NICU infants with bilateral hearing loss: a multi-centre longitudinal cohort study.Frontiers in neuroscience · 2026Article
- Early developmental trajectory phenotypes for risk stratification of autism spectrum disorder in very preterm infants: a machine learning approach.Molecular autism · 2025Article
- Neonatal neurodevelopmental follow-up in the UK: a survey of current practice and future recommendations.BMC pediatrics · 2025Article
- Pilot feasibility study of a digital technology approach to the systematic electronic capture of parent-reported data on cognitive and language development in children aged 2 years.BMJ health & care informatics · 2023Article
- Recurrence risk factors of intravitreal ranibizumab monotherapy in retinopathy of prematurity: a retrospective study at one center.International journal of ophthalmology · 2023Article
- Short-term neurodevelopment and growth outcomes of very and moderate preterm Indian infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Microglial iron trafficking: new player in brain injury.Turkish journal of medical sciences · 2022Review
- Never-breastfed children face a higher risk of suboptimal cognition at 2 years of corrected age: A multinational cohort of very preterm children.Maternal & child nutrition · 2022Article
- Machine learning methods to predict attrition in a population-based cohort of very preterm infants.Scientific reports · 2022Article
- Association of Abnormal Findings on Neonatal Cranial Ultrasound With Neurobehavior at Neonatal Intensive Care Unit Discharge in Infants Born Before 30 Weeks' Gestation.JAMA network open · 2022Article
- Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age.BMC medical research methodology · 2021Article
- Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population.JAMA network open · 2021Article
- Average 2.5-year neurodevelopmental test results in children born very preterm did not rule out cognitive deficits at 6.5 years of age.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Developmental Trajectories in Very Preterm Born Children Up to 8 Years: A Longitudinal Cohort Study.Frontiers in pediatrics · 2021Article
- Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort.International journal of epidemiology · 2020Article
- The effect of very preterm birth on the Five-Factor Model of personality traits: A meta-analysis of individual participant data.European journal of personalityArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether the variation in neurodevelopmental disability rates between populations persists after adjustment for demographic, maternal and infant characteristics for an international very preterm (VPT) birth cohort using a standardised approach to neurodevelopmental assessment at 2 years of age.
designProspective standardised cohort study.
setting15 regions in 10 European countries. PATIENTS: VPT births: 22 DATA COLLECTION: Standardised data collection tools relating to pregnancy, birth and neonatal care and developmental outcomes at 2 years corrected age using a validated parent completed questionnaire.
main outcome measuresCrude and standardised prevalence ratios calculated to compare rates of moderate to severe neurodevelopmental impairment between regions grouped by country using fixed effects models.
resultsParent reported rates of moderate or severe neurodevelopmental impairment for the cohort were: 17.3% (ranging 10.2%-26.1% between regions grouped by country) with crude standardised prevalence ratios ranging from 0.60 to 1.53. Adjustment for population, maternal and infant factors resulted in a small reduction in the overall variation (ranging from 0.65 to 1.30).
conclusionThere is wide variation in the rates of moderate to severe neurodevelopmental impairment for VPT cohorts across Europe, much of which persists following adjustment for known population, maternal and infant factors. Further work is needed to investigate whether other factors including quality of care and evidence-based practice have an effect on neurodevelopmental outcomes for these children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.